The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Activation of the Budding Yeast Spindle Assembly Checkpoint Without Mitotic Spindle Disruption
Abstract
The spindle assembly checkpoint keeps cells with defective spindles from initiating chromosome segregation. The protein kinase Mps1 phosphorylates the yeast protein Mad1p when this checkpoint is activated, and the overexpression of Mps1p induces modification of Mad1p and arrests wild-type yeast cells in mitosis with morphologically normal spindles. Spindle assembly checkpoint mutants overexpressing Mps1p pass through mitosis without delay and can produce viable progeny, which demonstrates that the arrest of wild-type cells results from inappropriate activation of the checkpoint in cells whose spindle is fully functional. Ectopic activation of cell-cycle checkpoints might be used to exploit the differences in checkpoint status between normal and tumor cells and thus improve the selectivity of chemotherapy.
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Cites
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Self-citationS. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
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A p53-Dependent Mouse Spindle Checkpoint
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Self-citation
Cited by
The spindle-assembly checkpoint in space and time
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The Spindle Assembly Checkpoint
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The Yeast ULP2 (SMT4) Gene Encodes a Novel Protease Specific for the Ubiquitin-Like Smt3 Protein
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The Mad2 spindle checkpoint protein has two distinct natively folded states
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Metadata
- Authors
- Hardwick, K. G., Weiss, E., Luca, F. C., Winey, M., & Murray, A. W.
- Venue
- Science
- Published
- 1996-08-16
- Volume
- 273
- Issue
- 5277
- Pages
- 953-956
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006389406
- Cited by
- 337
- References
- 19
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hardwick, K. G., Weiss, E., Luca, F. C., Winey, M., & Murray, A. W. (1996). Activation of the Budding Yeast Spindle Assembly Checkpoint Without Mitotic Spindle Disruption. Science. https://doi.org/10.1126/science.273.5277.953
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
