The DOI matches its Crossref record.
Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells
Abstract
The possibility of using the vascular endothelial cell as a target for gene replacement therapy was explored. Recombinant retroviruses were used to transduce the lacZ gene into endothelial cells harvested from mongrel dogs. Prosthetic vascular grafts seeded with the genetically modified cells were implanted as carotid interposition grafts into the dogs from which the original cells were harvested. Analysis of the graft 5 weeks after implantation revealed genetically modified endothelial cells lining the luminal surface of the graft. This technology could be used in the treatment of atherosclerosis disease and the design of new drug delivery systems.
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Citations
Cited by
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
Langer, R. (1990) · Science · doi:10.1126/science.2218494 · Cited by 1,778
Lemarchand, P., Jones, M., Yamada, I., & Crystal, R. G. (1993) · Circulation Research · doi:10.1161/01.res.72.5.1132 · Cited by 257
Metadata
- Authors
- Wilson, J. M., Birinyi, L. K., Salomon, R. N., Libby, P., Callow, A. D., & Mulligan, R. C.
- Venue
- Science
- Published
- 1989-06-16
- Volume
- 244
- Issue
- 4910
- Pages
- 1344-1346
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982224993
- Cited by
- 337
- References
- 0
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells. https://app.cochat.ai/papers/10.1126/science.2734614
- The paper
- Wilson, J. M., Birinyi, L. K., Salomon, R. N., Libby, P., Callow, A. D., & Mulligan, R. C. (1989). Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells. Science. https://doi.org/10.1126/science.2734614
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
