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Cited by 783

The DOI matches its Crossref record.

Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores

Chen, Rey-Huei, Waters, Jennifer C., Salmon, E. D., Murray, Andrew W.·1996·Science
DOI 10.1126/science.274.5285.242
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Abstract

The spindle assembly checkpoint delays anaphase until all chromosomes are attached to a mitotic spindle. The mad (mitotic arrest-deficient) and bub (budding uninhibited by benzimidazole) mutants of budding yeast lack this checkpoint and fail to arrest the cell cycle when microtubules are depolymerized. A frog homolog of MAD2 ( XMAD2 ) was isolated and found to play an essential role in the spindle assembly checkpoint in frog egg extracts. XMAD2 protein associated with unattached kinetochores in prometaphase and in nocodazole-treated cells and disappeared from kinetochores at metaphase in untreated cells, suggesting that XMAD2 plays a role in the activation of the checkpoint by unattached kinetochores. This study furthers understanding of the mechanism of cell cycle checkpoints in metazoa and provides a marker for studying the role of the spindle assembly checkpoint in the genetic instability of tumors.

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Metadata

Authors
Chen, R.-H., Waters, J. C., Salmon, E. D., & Murray, A. W.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-10-11
Volume
274
Issue
5285
Pages
242-246
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.274.5285.242
OpenAlex
W2048735610
Cited by
783
References
0
FWCI
18.30
Type
journal article
Language
en
Open access
closed

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