The DOI matches its Crossref record.
Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor
Abstract
The mechanisms that maintain the epithelial integrity of the gastrointestinal tract remain largely undefined. The gene encoding intestinal trefoil factor (ITF), a protein secreted throughout the small intestine and colon, was rendered nonfunctional in mice by targeted disruption. Mice lacking ITF had impaired mucosal healing and died from extensive colitis after oral administration of dextran sulfate sodium, an agent that causes mild epithelial injury in wild-type mice. ITF-deficient mice manifested poor epithelial regeneration after injury. These findings reveal a central role for ITF in the maintenance and repair of the intestinal mucosa.
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Cited by
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Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
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Metadata
- Authors
- Mashimo, H., Wu, D.-C., Podolsky, D. K., & Fishman, M. C.
- Venue
- Science
- Published
- 1996-10-11
- Volume
- 274
- Issue
- 5285
- Pages
- 262-265
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981327571
- Cited by
- 701
- References
- 0
- FWCI
- 18.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mashimo, H., Wu, D.-C., Podolsky, D. K., & Fishman, M. C. (1996). Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor. Science. https://doi.org/10.1126/science.274.5285.262
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
