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Cited by 918

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

Hotamisligil, Gökhan S., Johnson, Randall S., Distel, Robert J., Ellis, Ramsey, Papaioannou, Virginia E., Spiegelman, Bruce M.·1996·Science
DOI 10.1126/science.274.5291.1377
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Abstract

Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind to fatty acids such as oleic and retinoic acid. Mice with a null mutation in aP2 , the gene encoding the adipocyte FABP, were developmentally and metabolically normal. The aP2 -deficient mice developed dietary obesity but, unlike control mice, they did not develop insulin resistance or diabetes. Also unlike their obese wild-type counterparts, obese aP2 −/− animals failed to express in adipose tissue tumor necrosis factor-α (TNF-α), a molecule implicated in obesity-related insulin resistance. These results indicate that aP2 is central to the pathway that links obesity to insulin resistance, possibly by linking fatty acid metabolism to expression of TNF-α.

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Citations

Cites

Research works printed but not linked: 19

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Cited by

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Metadata

Authors
Hotamisligil, G. S., Johnson, R. S., Distel, R. J., Ellis, R., Papaioannou, V. E., & Spiegelman, B. M.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-11-22
Volume
274
Issue
5291
Pages
1377-1379
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.274.5291.1377
OpenAlex
W2060952287
Cited by
918
References
6
FWCI
26.67
Type
journal article
Language
en
Open access
closed

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