The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 + T Cell Turnover
Abstract
Progression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion of the regenerative capacity of the immune system resulting from high T cell turnover. Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular replicative history, showed that CD8 + T cell TRF length decreased but CD4 + T cell TRF length was stable during the course of human immunodeficiency virus type-1 (HIV-1) infection, which was not explained by differential telomerase activity. This observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8 + T cells, but not in CD4 + T cells. These results are compatible with CD4 + T cell decline in HIV-1 infection caused by interference with cell renewal.
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“These finds were also independent on whether HIV patients were on antiretroviral therapy (Effros et al, 1996; Wolthers et al, 1996; Palmer et al, 1997).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Wolthers et al, 1996
In the citing paper
“Interestingly, certain hallmarks of cellular senescence are also found in T cells from patients with HIV (Effros et al, 1996; Wolthers et al, 1996; Palmer et al, 1997; Nelson et al, 2012; Pereira Ribeiro et al, 2016).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Wolthers et al, 1996
In the citing paper
“Telomere lengths of CD8+ T cells are shorter in HIV patients compared to healthy individuals, but this observation was not found in CD4+ T cells.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Wolthers et al, 1996
In the citing paper
“Telomere lengths of CD8+ T cells are shorter in HIV patients compared to healthy individuals, but this observation was not found in CD4+ T cells.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Wolthers et al, 1996
Citations
Cites
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Cited by
Sorted by citations
Autran, B., Carcelain, G., Li, T., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debré, P., & Leibowitch, J. (1997) · Science · doi:10.1126/science.277.5322.112 · Cited by 1,786
Giorgi, J. V., Hultin, L. E., McKeating, J. A., Johnson, T. D., Owens, B. M., Jacobson, L. P., Shih, R., Lewis, J., Wiley, D. J., Phair, J. P., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/314660 · Cited by 1,032
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002
Persistent immune activation in HIV-1 infection is associated with progression to AIDS
Hazenberg, M. D., Otto, S. A., BENTHEM, B. H. B. V., Roos, M. T. L., Coutinho, R. A., Lange, J. M. A., Hamann, D., Prins, M., & Miedema, F. F. (2003) · AIDS · doi:10.1097/00002030-200309050-00006 · Cited by 764
Self-citationTelomere length, stem cells and aging
Blasco, M. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.38 · Cited by 747
Metadata
- Authors
- Wolthers, K. C., Bea, G., Wisman, A., Otto, S. A., de Roda Husman, A.-M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R. A., van der Zee, A. G. J., Meyaard, L., & Miedema, F.
- Affiliations
- University of Amsterdam (NL)
- University Medical Center Groningen (NL)
- K. C. Wolthers, S. A. Otto, A.-M. de Roda Husman, N. Schaft, L. Meyaard, Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, Amsterdam, Netherlands.
- F. de Wolf and J. Goudsmit, Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
- Amsterdam UMC Location University of Amsterdam (NL)
- GGD Amsterdam (NL)
- G. B. A. Wisman and A. G. J. van der Zee, Department of Gynaecology and Obstetrics, Academic Hospital Groningen, University of Groningen, Groningen, Netherlands.
- Corresponding author
- Miedema, Frank
- Venue
- Science
- Published
- 1996-11-29
- Volume
- 274
- Issue
- 5292
- Pages
- 1543-1547
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055875053
- Cited by
- 286
- References
- 58
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 5
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- HIV-1 infection, telomere length, terminal restriction fragments, CD4+ T cells, CD8+ T cells, T cell turnover, telomerase activity, immunosenescence, AIDS progression
- MeSH terms
- Acquired Immunodeficiency Syndrome, Cell Division, Cross-Sectional Studies, Humans, Leukocytes, Mononuclear, Male, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Matched-Pair Analysis, Telomere, Cell Death, CD8-Positive T-Lymphocytes, Disease Progression, Lymphocyte Count, CD4 Lymphocyte Count, Telomerase
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