Cited by 287HIV Research and TreatmentTelomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 + T Cell Turnover

Wolthers, Katja C., Bea, G., Wisman, A., Otto, Sigrid A., de Roda Husman, Ana-Maria, Schaft, Niels, de Wolf, Frank, Goudsmit, Jaap, Coutinho, Roel A., van der Zee, Ate G. J., Meyaard, Linde, Miedema, Frank·1996·Science

DOI 10.1126/science.274.5292.1543

Open this paper in CoChat — free account

Abstract

Progression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion of the regenerative capacity of the immune system resulting from high T cell turnover. Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular replicative history, showed that CD8 + T cell TRF length decreased but CD4 + T cell TRF length was stable during the course of human immunodeficiency virus type-1 (HIV-1) infection, which was not explained by differential telomerase activity. This observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8 + T cells, but not in CD4 + T cells. These results are compatible with CD4 + T cell decline in HIV-1 infection caused by interference with cell renewal.

Integrity signals

Registry

Crossref · 10.1126/science.274.5292.1543

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M., & Markowitz, M. H. (1995) · Nature · doi:10.1038/373123a0 · Cited by 4,261
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time
Perelson, A. S., Neumann, A. U., Markowitz, M. H., Leonard, J. M., & Ho, D. D. (1996) · Science · doi:10.1126/science.271.5255.1582 · Cited by 3,533
Viral dynamics in human immunodeficiency virus type 1 infection
Wei, X., Ghosh, S. K., Taylor, M. E., Johnson, V. A., Emini, E. A., Deutsch, P., Lifson, J. D., Bonhoeffer, S., Nowak, M. A., Hahn, B. H., et al. (1995) · Nature · doi:10.1038/373117a0 · Cited by 3,259
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096
Untitled work
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847

Show all 58 references

Research works printed but not linked: 7

Bofill M., et al., ibid. 10, 827 (1996).
Gougeon M., Montagnier L., ibid. 260, 1269 (1993);
Muro-Cacho C. A., Pantaleo G., Fauci A. S., ibid. 154, 5555 (1995).
Morin G. B., ibid. 59, 521 (1989);
Vaziri H., et al., Am. J. Hum. Genet. 52, 661 (1993).
Slagboom P. E., Droog S., Boomsma D. I., Am. J. Hum. Genet. 55, 876 (1994).
De Lange T., et al., Mol. Cell. Biol. 10, 518 (1990).

Sorted by citations

Positive Effects of Combined Antiretroviral Therapy on CD4 + T Cell Homeostasis and Function in Advanced HIV Disease
Autran, B., Carcelain, G., Li, T., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debré, P., & Leibowitch, J. (1997) · Science · doi:10.1126/science.277.5322.112 · Cited by 1,786
Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage
Giorgi, J. V., Hultin, L. E., McKeating, J. A., Johnson, T. D., Owens, B. M., Jacobson, L. P., Shih, R., Lewis, J., Wiley, D. J., Phair, J. P., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/314660 · Cited by 1,032
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002
Persistent immune activation in HIV-1 infection is associated with progression to AIDS
Hazenberg, M. D., Otto, S. A., BENTHEM, B. H. B. V., Roos, M. T. L., Coutinho, R. A., Lange, J. M. A., Hamann, D., Prins, M., & Miedema, F. F. (2003) · AIDS · doi:10.1097/00002030-200309050-00006 · Cited by 764
Self-citation
Telomere length, stem cells and aging
Blasco, M. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.38 · Cited by 747
Immune activation and inflammation in HIV‐1 infection: causes and consequences
Appay, V., & Sauce, D. (2007) · The Journal of Pathology · doi:10.1002/path.2276 · Cited by 780
Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
Pakker, N. G., Notermans, D. W., de Boer, R. J., Roos, M. T. L., de Wolf, F., Hill, A., Leonard, J. M., Danner, S. A., Miedema, F. F., & Schellekens, P. T. A. (1998) · Nature Medicine · doi:10.1038/nm0298-208 · Cited by 701
Self-citation
Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
Hellerstein, M. K., Hanley, M. B., Cesar, D., Siler, S., Papageorgopoulos, C., Wieder, E., Schmidt, D. J., Hoh, R., Neese, R. A., Macallan, D. C., et al. (1999) · Nature Medicine · doi:10.1038/4772 · Cited by 592
Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
Rufer, N., Dragowska, W. H., Thornbury, G., Roosnek, E. E., & Lansdorp, P. M. (1998) · Nature Biotechnology · doi:10.1038/nbt0898-743 · Cited by 551
POPULATION BIOLOGY OF HIV-1 INFECTION: Viral and CD4 + T Cell Demographics and Dynamics in Lymphatic Tissues
Haase, A. T. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.625 · Cited by 541
The Role of the Thymus in Immune Reconstitution in Aging, Bone Marrow Transplantation, and HIV-1 Infection
Haynes, B. F., Markert, M. L., Sempowski, G. D., Patel, D. D., & Hale, L. P. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.529 · Cited by 512
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Papagno, L., Spina, C. A., Marchant, A., Salio, M., Rufer, N., Little, S., Dong, T., Chesney, G., Waters, A., Easterbrook, P., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020020 · Cited by 478
T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)
Hazenberg, M. D., Stuart, J. W. T. C., Otto, S. A., Borleffs, J. C. C., Boucher, C. A., de Boer, R. J., Miedema, F. F., & Hamann, D. (2000) · Blood · doi:10.1182/blood.v95.1.249 · Cited by 452
Self-citation
HIV-1 pathogenesis
Stevenson, M. (2003) · Nature Medicine · doi:10.1038/nm0703-853 · Cited by 455
Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4
Herbein, G., Mahlknecht, U., Batliwalla, F., Gregersen, P. K., Pappas, T. C., Butler, J., O’Brien, W. A., & Verdin, E. M. (1998) · Nature · doi:10.1038/26026 · Cited by 400
Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection
Hazenberg, M. D., Otto, S. A., Stuart, J. W. T. C., Verschuren, M. C. M., Borleffs, J. C. C., Boucher, C. A., Coutinho, R. A., Lange, J. M. A., de Wit, T. F. R., Tsegaye, A., et al. (2000) · Nature Medicine · doi:10.1038/79549 · Cited by 393
Self-citation
T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock
Hazenberg, M. D., Hamann, D., Schuitemaker, H., & Miedema, F. F. (2000) · Nature Immunology · doi:10.1038/79724 · Cited by 383
Self-citation
Rapid Turnover of T Lymphocytes in SIV-Infected Rhesus Macaques
Mohri, H., Bonhoeffer, S., Monard, S. P., Perelson, A. S., & Ho, D. D. (1998) · Science · doi:10.1126/science.279.5354.1223 · Cited by 368
Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy
Mohri, H., Perelson, A. S., Tung, K. S., Ribeiro, R. M., Ramratnam, B., Markowitz, M. H., Kost, R. G., Hurley, Weinberger, L. S., Cesar, D., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1277 · Cited by 359
T cells and aging
Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357
Initial increase in blood CD4+ lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues
Bucy, R. P., Hockett, R. D., Derdeyn, C. A., Saag, M. S., Squires, K., Sillers, M., Mitsuyasu, R. T., & Kilby, J. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5863 · Cited by 330
Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen
Sachsenberg, N., Perelson, A. S., Yerly, S., Schockmel, G. A., Leduc, D., Hirschel, B. J., & Perrin, L. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.8.1295 · Cited by 329
Telomeres in T and B cells
Hodes, R. J., Hathcock, K. S., & Weng, N. (2002) · Nature reviews. Immunology · doi:10.1038/nri890 · Cited by 317
In vivo HIV-1 infection of CD45RA + CD4 + T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4 + T cell decline
Blaak, H., Wout, A. B. V. ’., Brouwer, M., Hooibrink, B., Hovenkamp, E., & Schuitemaker, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1269 · Cited by 262
High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.
McCune, J. M., Loftus, R., Schmidt, D. K., Carroll, P. R., Webster, D., Swor-Yim, L. B., Francis, I. R., Gross, B. H., & Grant, R. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2834 · Cited by 250
Quantifying T lymphocyte turnover
de Boer, R. J., & Perelson, A. S. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.12.025 · Cited by 242
CD8+ T-Lymphocyte Activation in HIV-1 Disease Reflects an Aspect of Pathogenesis Distinct From Viral Burden and Immunodeficiency
Liu, Z., Cumberland, W. G., Hultin, L. E., Kaplan, A. H., Detels, R., & Giorgi, J. V. (1998) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199808010-00004 · Cited by 237
Identification of Dynamically Distinct Subpopulations of T Lymphocytes That Are Differentially Affected by HIV
Kovacs, J. A., Lempicki, R. A., Sidorov, I. A., Adelsberger, J. W., Herpin, B. R., Metcalf, J. A., Sereti, I., Polis, M. A., Davey, R. T., Tavel, J. A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.12.1731 · Cited by 222
Shortened telomere length in white blood cells of patients with IDDM.
Jeanclos, E., Krolewski, A., Skurnick, J., Kimura, M., Aviv, H., Warram, J. H., & Aviv, A. (1998) · Diabetes · doi:10.2337/diabetes.47.3.482 · Cited by 217
Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
Weng, N., Palmer, L. D., Levine, B. L., Lane, H. C., June, C. H., & Hodes, R. J. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01026.x · Cited by 201
In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: Why are CD4 + but not CD8 + T cells depleted?
Ribeiro, R. M., Mohri, H., Ho, D. D., & Perelson, A. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242358099 · Cited by 199
Rapid Telomere Shortening in Children
Zeichner, S. L., Palumbo, P. E., Feng, Y., Xiao, X., Gee, D., Sleasman, J. W., Goodenow, M. M., Biggar, R. J., & Dimitrov, D. S. (1999) · Blood · doi:10.1182/blood.v93.9.2824.409k18_2824_2830 · Cited by 195
Telomere shortening in human diseases
Kong, C. M., Lee, X. W., & Wang, X. (2013) · The FEBS Journal · doi:10.1111/febs.12326 · Cited by 194
HIV as a Cause of Immune Activation and Immunosenescence
Sokoya, T., Steel, H. C., Nieuwoudt, M., & Rossouw, T. M. (2017) · Mediators of Inflammation · doi:10.1155/2017/6825493 · Cited by 198
Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies in vitro , in animals, and in humans
Macallan, D. C., Fullerton, C. A., Neese, R. A., Haddock, K., Park, S. S., & Hellerstein, M. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.708 · Cited by 190
The Unenlarged Lymph Nodes of HIV-1–infected, Asymptomatic Patients with High CD4 T Cell Counts Are Sites for Virus Replication and CD4 T Cell Proliferation. The Impact of Highly Active Antiretroviral Therapy
Tenner‐Racz, K., Stellbrink, H., van Lunzen, J., Schneider, C. G., Jacobs, J.-P., Raschdorff, B., Groβschupff, G., Steinman, R. M., & Rácz, P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.949 · Cited by 187
Incomplete Immune Recovery in HIV Infection: Mechanisms, Relevance for Clinical Care, and Possible Solutions
Gaardbo, J. C., Hartling, H. J., Gerstoft, J., & Nielsen, S. D. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/670957 · Cited by 183
Premature ageing of the immune system: the cause of AIDS?
Appay, V., & Rowland-Jones, S. L. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02338-4 · Cited by 173
Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS
Zagury, D., Lachgar, A., Chams, V., Fall, L. S., Bernard, J., Zagury, J., Bizzini, B., Gringeri, A., Santagostino, E., Rappaport, J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3851 · Cited by 172
HIV, Age, and the Severity of Hepatitis C Virus–Related Liver Disease
Kirk, G. D., Mehta, S. H., Astemborski, J. A., Galai, N., Washington, J., Higgins, Y., Balagopal, A., & Thomas, D. L. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-9-201305070-00604 · Cited by 173
T Cell Homeostasis
Almeida, A. R. M., Borghans, J. A. M., & Freitas, A. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.591 · Cited by 166
HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy
Hearps, A. C., Maisa, A., Cheng, W., Angelovich, T. A., Lichtfuss, G. F., Palmer, C. S., LANDAY, A. L., Jaworowski, A., & Crowe, S. M. (2012) · AIDS · doi:10.1097/qad.0b013e328351f756 · Cited by 159
Immune activation in the course of HIV ‐1 infection: Causes, phenotypes and persistence under therapy
Younas, M., Psomas, C. K., Reynes, J., & Corbeau, P. (2015) · HIV Medicine · doi:10.1111/hiv.12310 · Cited by 159
Regulation of Telomere Length and Telomerase in T and B Cells
Weng, N., Hathcock, K. S., & Hodes, R. J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80597-x · Cited by 157
In vivo analysis of Fas/FasL interactions in HIV-infected patients.
Badley, A. D., Dockrell, D. H., Algeciras, A., Ziesmer, S., LANDAY, A. L., Lederman, M. M., Connick, E., Kessler, H. A., Kuritzkes, D. R., Lynch, D. H., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2691 · Cited by 150
Limited CD4+ T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy
Fleury, S., de Boer, R. J., Rizzardi, G. P., Wolthers, K. C., Otto, S. A., Welbon, C. C., Graziosi, C., Knabenhans, C., Soudeyns, H., Bart, P.-A., et al. (1998) · Nature Medicine · doi:10.1038/nm0798-794 · Cited by 147
Self-citation
Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence.
Dock, J., & Effros, R. B. (2011) · Europe PMC (PubMed Central) · Cited by 137
The mucosal immune system: primary target for HIV infection and AIDS
Veazey, R. S., Marx, P. A., & Lackner, A. A. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)02039-7 · Cited by 133
Synchrony in telomere length of the human fetus
Youngren, K., Jeanclos, E., Aviv, H., Kimura, M., Stock, J., Hanna, M., Skurnick, J., Bardeguez, A., & Aviv, A. (1998) · Human Genetics · doi:10.1007/s004390050755 · Cited by 130
Measurement and modeling of human T cell kinetics
Macallan, D. C., Asquith, B., Irvine, A. J., Wallace, D. L., Worth, A. T., Ghattas, H., Zhang, Y., Griffin, G. E., Tough, D. F., & Beverley, P. C. L. (2003) · European Journal of Immunology · doi:10.1002/eji.200323763 · Cited by 129
Turnover Rates of B Cells, T Cells, and NK Cells in Simian Immunodeficiency Virus-Infected and Uninfected Rhesus Macaques
de Boer, R. J., Mohri, H., Ho, D. D., & Perelson, A. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2479 · Cited by 120
Accelerated telomere shortening and telomerase activation in Fanconi's anaemia
Leteurtre, F., Li, X., Guardiola, P., Roux, G. L., Sergère, J., Richard, P., Carosella, E. D., & Gluckman, É. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01445.x · Cited by 119
Immunological memory
Sprent, J. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80084-2 · Cited by 120
Viruses and neurodegeneration
Zhou, L., Saksena, M. M., & Saksena, N. K. (2013) · Virology Journal · doi:10.1186/1743-422x-10-172 · Cited by 121
T Cell Turnover in HIV-1 Disease
Hellerstein, M. K., & McCune, J. M. (1997) · Immunity · doi:10.1016/s1074-7613(00)80379-9 · Cited by 112
Virus-Induced CD8+ T Cell Clonal Expansion Is Associated with Telomerase Up-Regulation and Telomere Length Preservation: A Mechanism for Rescue from Replicative Senescence
Maini, M. K., Soares, M. V. D., Zilch, C. F., Akbar, A. N., & Beverley, P. C. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4521 · Cited by 110
Aging with HIV: a practical review
Cardoso, S. W., Torres, T. S., Santini-Oliveira, M., Marins, L. M. S., Veloso, V. G., & Grinsztejn, B. G. J. (2013) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2012.11.007 · Cited by 108
Risk of coronary heart disease in patients with HIV infection
Zanni, M. V., Schouten, J., Grinspoon, S. K., & Reiss, P. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.167 · Cited by 107
Human Immunodeficiency Virus Type 1 Infection Is Associated with Significant Mucosal Inflammation Characterized by Increased Expression of CCR5, CXCR4, and β‐Chemokines
Olsson, J., Poles, M. A., Spetz, A., Elliott, J. E., Hultin, L. E., Giorgi, J. V., Andersson, J., & Anton, P. A. (2000) · The Journal of Infectious Diseases · doi:10.1086/317625 · Cited by 104
Frailty in HIV: Epidemiology, Biology, Measurement, Interventions, and Research Needs
Piggott, D. A., Erlandson, K. M., & Yarasheski, K. E. (2016) · Current HIV/AIDS Reports · doi:10.1007/s11904-016-0334-8 · Cited by 108
Increased rates of CD4 + and CD8 + T lymphocyte turnover in simian immunodeficiency virus-infected macaques
Rosenzweig, M., DeMaria, M., Harper, D. M., Friedrich, S. W., Jain, R. K., & Johnson, R. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6388 · Cited by 99
HIV-induced decline in blood CD4/CD8 ratios: viral killing or altered lymphocyte trafficking?
Rosenberg, Y. J., Anderson, A. O., & Pabst, R. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01183-3 · Cited by 99
Assessment of Type 1 and Type 2 Cytokines in HIV Type 1-Infected Individuals: Impact of Highly Active Antiretroviral Therapy
Imami, N., Antonopoulos, C., Hardy, G. A. D., Gazzard, B., & Gotch, F. M. (1999) · AIDS Research and Human Retroviruses · doi:10.1089/088922299309784 · Cited by 95
Accelerated replicative senescence of the peripheral immune system induced by HIV infection
Bestilny, L. J., Gill, M. J., Mody, C. H., & Riabowol, K. T. (2000) · AIDS · doi:10.1097/00002030-200005050-00002 · Cited by 95
Measurement of T-cell kinetics: recent methodologic advances
Hellerstein, M. K. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01529-7 · Cited by 92
Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system
van Baarle, D., Tsegaye, A., Miedema, F. F., & Akbar, A. N. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.10.003 · Cited by 91
Self-citation
The Dominant Source of CD4+ and CD8+ T-Cell Activation in HIV Infection Is Antigenic Stimulation
Stuart, J. W. T. C., Hazebergh, M. D., Hamann, D., Otto, S. A., Borleffs, J. C. C., Miedema, F. F., Boucher, C. A., & de Boer, R. J. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00042560-200011010-00001 · Cited by 90
Self-citation
Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy
Fleury, S., Rizzardi, G. P., Chapuis, A. G., Tambussi, G., Knabenhans, C., Simeoni, E., Meuwly, J., Corpataux, J.-M., Lazzarin, A., Miedema, F. F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5393 · Cited by 87
Self-citation
Human Immunodeficiency Virus-1 Infection Interrupts Thymopoiesis and Multilineage Hematopoiesis In Vivo
Jenkins, M., Hanley, M. B., Moreno, M. B., Wieder, E., & McCune, J. M. (1998) · Blood · doi:10.1182/blood.v91.8.2672.2672_2672_2678 · Cited by 89
Treatment of Human Immunodeficiency Virus Infection with Hydroxyurea, Didanosine, and a Protease Inhibitor before Seroconversion Is Associated with Normalized Immune Parameters and Limited Viral Reservoir
Lori, F., Jessen, H. K., Lieberman, J., Finzi, D., Rosenberg, E. S., Tinelli, C., Walker, B. D., Siliciano, R. F., & Lisziewicz, J. (1999) · The Journal of Infectious Diseases · doi:10.1086/315113 · Cited by 85
Differential Impairment of Lytic and Cytokine Functions in Senescent Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes
Dagarag, M. D., Ng, H. L., Lubong, R., Effros, R. B., & Yang, O. O. (2003) · Journal of Virology · doi:10.1128/jvi.77.5.3077-3083.2003 · Cited by 85
Biochemical mechanisms of HIV induced T cell apoptosis
Selliah, N., & Finkel, T. H. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400822 · Cited by 86
In Vitro Replication Kinetics of Human Immunodeficiency Virus Type 1 (HIV‐1) Variants in Relation to Virus Load in Long‐Term Survivors of HIV‐1 Infection
Blaak, H., Brouwer, M., Ran, L., de Wolf, F., & Schuitemaker, H. (1998) · The Journal of Infectious Diseases · doi:10.1086/514219 · Cited by 84
Telomerase activity of HIV-1–specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
Lichterfeld, M. D., Mou, D., Cung, T. D. H., Williams, K. L., Waring, M. T., Huang, J., Pereyra, F., Piechocka‐Trocha, A., Freeman, G. J., Rosenberg, E. S., et al. (2008) · Blood · doi:10.1182/blood-2008-01-135442 · Cited by 88
Self-Renewal of Stem Cells
Lansdorp, P. M. (1998) · Humana Press eBooks · doi:10.1007/978-1-4757-2778-4_2 · Cited by 82
CD8hi+CD57+ T lymphocytes are enriched in antigen-specific T cells capable of down-modulating cytotoxic activity
Mollet, L. (1998) · International Immunology · doi:10.1093/intimm/10.3.311 · Cited by 81
Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes
Yang, O. O., Lin, H., Dagarag, M., Ng, H. L., Effros, R. B., & Uittenbogaart, C. H. (2005) · Virology · doi:10.1016/j.virol.2004.11.028 · Cited by 79
Costimulatory mechanisms in the elderly
Effros, R. B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00503-4 · Cited by 79
Immunosenescence in HIV Pathogenesis
Pommier, J., Gauthier, L., Livartowski, J., Galanaud, P., Boué, F., Dulioust, A., Marcé, D., Ducray, C., Sabatier, L., Lebeau, J., et al. (1997) · Virology · doi:10.1006/viro.1997.8512 · Cited by 74
Direct HIV Cytopathicity Cannot Account for CD4 Decline in AIDS in the Presence of Homeostasis: A Worst-Case Dynamic Analysis
Anderson, R. W., Ascher, M. S., & Sheppard, H. W. (1998) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199803010-00010 · Cited by 73
CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway
Tateyama, M., Oyaizu, N., McCloskey, T. W., Than, S., & Pahwa, S. G. (2000) · Blood · doi:10.1182/blood.v96.1.195 · Cited by 72
T-cell homeostasis in HIV infection is neither failing nor blind: Modified cell counts reflect an adaptive response of the host
Grossman, Z., & Herberman, R. B. (1997) · Nature Medicine · doi:10.1038/nm0597-486 · Cited by 69
Open Science: the Very Idea
Miedema, F. F. (2021) · Springer eBooks · doi:10.1007/978-94-024-2115-6 · Cited by 81
Self-citation
Rapid CD4+ T-cell turnover in HIV-1 infection: A paradigm revisited
Wolthers, K. C., Schuitemaker, H., & Miedema, F. F. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01188-2 · Cited by 67
Self-citation
Human Ageing and Telomeres
Harley, C. B. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515433.ch9 · Cited by 67
T Cell Dynamics in HIV-1 Infection
Clark, D. R., de Boer, R. J., Wolthers, K. C., & Miedema, F. F. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60789-0 · Cited by 68
Self-citation
Model of HIV-1 Disease Progression Based on Virus-Induced Lymph Node Homing and Homing-Induced Apoptosis of CD4+ Lymphocytes
Kirschner, D. E., Webb, G. F., & Cloyd, M. W. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200008010-00010 · Cited by 64
Assessing immune aging in HIV-infected patients
Appay, V., & Sauce, D. (2016) · Virulence · doi:10.1080/21505594.2016.1195536 · Cited by 68
Increased peripheral expansion of naive CD4+ T cells in vivo after IL-2 treatment of patients with HIV infection
Natarajan, V., Lempicki, R. A., Sereti, I., Badralmaa, Y., Adelsberger, J. W., Metcalf, J. A., Prieto, D. A., Stevens, R. A., Baseler, M., Kovacs, J. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162352399 · Cited by 65
Differential Dynamics of CD4+and CD8+T-Lymphocyte Proliferation and Activation in Acute Simian Immunodeficiency Virus Infection
Kaur, A., Hale, C. L., Ramanujan, S., Jain, R. K., & Johnson, R. P. (2000) · Journal of Virology · doi:10.1128/jvi.74.18.8413-8424.2000 · Cited by 65
Inadequate Clearance of Translocated Bacterial Products in HIV-Infected Humanized Mice
Hofer, U., Schlaepfer, E., Baenziger, S., Nischang, M., Regenass, S., Schwendener, R. A., Kempf, W., Nadal, D., & Speck, R. F. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000867 · Cited by 66
The lymph node in HIV pathogenesis
Lederman, M. M., & Margolis, L. B. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.06.001 · Cited by 67
In vitro senescence of immune cells
Effros, R. B., Dagarag, M. D., & Valenzuela, H. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.004 · Cited by 62
AIDS pathogenesis: what have two decades of HIV research taught us?
Rowland‐Jones, S. (2003) · Nature reviews. Immunology · doi:10.1038/nri1058 · Cited by 70
The pathogenesis of HIV-1 infection
Weber, J. (2001) · British Medical Bulletin · doi:10.1093/bmb/58.1.61 · Cited by 57
The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence
Heath, J., & Grant, M. D. (2020) · Cells · doi:10.3390/cells9030766 · Cited by 57
TGF-β induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia
Schlapbach, R., Spanaus, K., Malipiero, U., Lens, S. M. A., Tasinato, A., Tschopp, J., & Fontana, A. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200012)30:12 · Cited by 74
HIV infection: where have all the T cells gone?
Rowland-Jones, S. L. (1999) · The Lancet · doi:10.1016/s0140-6736(99)90017-x · Cited by 55
Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy
Epps, P. V., & Kalayjian, R. C. (2017) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.07.007 · Cited by 56
The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52

Authors: Wolthers, K. C., Bea, G., Wisman, A., Otto, S. A., de Roda Husman, A.-M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R. A., van der Zee, A. G. J., Meyaard, L., & Miedema, F.
Affiliations: University of Amsterdam (NL)
University Medical Center Groningen (NL)
K. C. Wolthers, S. A. Otto, A.-M. de Roda Husman, N. Schaft, L. Meyaard, Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, Amsterdam, Netherlands.
F. de Wolf and J. Goudsmit, Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
Amsterdam UMC Location University of Amsterdam (NL)
GGD Amsterdam (NL)
G. B. A. Wisman and A. G. J. van der Zee, Department of Gynaecology and Obstetrics, Academic Hospital Groningen, University of Groningen, Groningen, Netherlands.
Corresponding author: Miedema, Frank
ORCID: Wolthers, Katja C.
Schaft, Niels
Meyaard, Linde
Miedema, Frank
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-11-29
Volume: 274
Issue: 5292
Pages: 1543-1547
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.274.5292.1543
OpenAlex: W2055875053
Cited by: 286
References: 58
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 5
FWCI: 8.82
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: HIV-1 infection, telomere length, terminal restriction fragments, CD4+ T cells, CD8+ T cells, T cell turnover, telomerase activity, immunosenescence, AIDS progression
MeSH terms: Acquired Immunodeficiency Syndrome, Cell Division, Cross-Sectional Studies, Humans, Leukocytes, Mononuclear, Male, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Matched-Pair Analysis, Telomere, Cell Death, CD8-Positive T-Lymphocytes, Disease Progression, Lymphocyte Count, CD4 Lymphocyte Count, Telomerase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 + T Cell Turnover

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks