The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells
Abstract
The products of the Rag1 and Rag2 genes drive genomic V(D)J rearrangements that assemble functional immunoglobulin and T cell antigen receptor genes. Expression of the Rag genes has been thought to be limited to developmentally immature lymphocyte populations that in normal adult animals are primarily restricted to the bone marrow and thymus. Abundant RAG1 and RAG2 protein and messenger RNA was detected in the activated B cells that populate murine splenic and Peyer's patch germinal centers. Germinal center B cells thus share fundamental characteristics of immature lymphocytes, raising the possibility that antigen-dependent secondary V(D)J rearrangements modify the peripheral antibody repertoire.
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Cites
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Intraclonal generation of antibody mutants in germinal centres
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Self-citationMaturation of the immune response in germinal centers
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Receptor editing in self-reactive bone marrow B cells.
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Self-citationHypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
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Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
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Cited by
Goossens, T., Klein, U., & Küppers, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2463 · Cited by 342
The Zebrafish as a Model Organism to Study Development of the Immune System
TRAVER, D., HERBOMEL, P., PATTON, E. E., MURPHEY, R. D., YODER, J. A., LITMAN, G. W., CATIC, A., AMEMIYA, C. T., ZON, L. I., & TREDE, N. S. (2003) · Advances in Immunology · doi:10.1016/s0065-2776(03)81007-6 · Cited by 276
Shaw, A. C., Swat, W., Ferrini, R., Davidson, L., & Alt, F. W. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.123 · Cited by 75
Inui, S., Maeda, K., Hua, D. R., Yamashita, T., Yamamoto, H., Miyamoto, E., Aizawa, S., & Sakaguchi, N. (2002) · International Immunology · doi:10.1093/intimm/14.2.177 · Cited by 19
Metadata
- Authors
- Han, S., Zheng, B., Schatz, D. G., Spanopoulou, E., & Kelsoe, G.
- Venue
- Science
- Published
- 1996-12-20
- Volume
- 274
- Issue
- 5295
- Pages
- 2094-2097
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077449764
- Cited by
- 263
- References
- 32
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells. https://app.cochat.ai/papers/10.1126/science.274.5295.2094
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- Han, S., Zheng, B., Schatz, D. G., Spanopoulou, E., & Kelsoe, G. (1996). Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells. Science. https://doi.org/10.1126/science.274.5295.2094
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
