The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Receptor editing in self-reactive bone marrow B cells.
Abstract
A central paradigm of immunology is clonal selection: lymphocytes displaying clonally distributed antigen receptors are generated and subsequently selected by antigen for growth or elimination. Here we show that in mice transgenic for anti-H-2Kk,b antibody genes, in which a homogeneous clone of developing B cells can be analyzed for the outcome of autoantigen encounter, surface immunoglobulin M+/idiotype+ immature B cells binding to self-antigens in the bone marrow are induced to alter the specificity of their antigen receptors. Transgenic bone marrow B cells encountering membrane-bound Kb or Kk proteins modify their receptors by expressing the V(D)J recombinase activator genes and assembling endogenously encoded immunoglobulin light chain variable genes. This (auto)antigen-directed change in the specificity of newly generated lymphocytes is termed receptor editing.
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Cites
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Self-citationReceptor editing: an approach by autoreactive B cells to escape tolerance.
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Cited by
Population Biology of Lymphocytes: The Flight for Survival
Freitas, A. A., & Rocha, B. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.83 · Cited by 426
Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice
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Contribution of Receptor Editing to the Antibody Repertoire
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Self-citationMicrobial colonization influences early B-lineage development in the gut lamina propria
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Enders, A., Bouillet, P., Puthalakath, H., Xu, Y., Tarlinton, D. M., & Strasser, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030411 · Cited by 295
Metadata
- Authors
- Tiegs, S. L., Russell, D. M., & Nemazee, D.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-04-01
- Volume
- 177
- Issue
- 4
- Pages
- 1009-1020
- ISSN
- 0022-1007
- 1540-9538
- Cited by
- 766
- References
- 60
- Language
- en
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