The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mechanics of Stimulated Neutrophils: Cell Stiffening Induces Retention in Capillaries
Abstract
The effect of peptide chemoattractants on neutrophil mechanical properties was studied to test the hypothesis that stimulated neutrophils (diameter, 8 micrometers) are retained in pulmonary capillaries (5.5 micrometers) as a result of a decreased ability of the cell to deform within the capillary in response to the hydrodynamic forces of the bloodstream. Increased neutrophil stiffness, actin assembly, and retention in both 5-micrometer pores and the pulmonary vasculature were seen in response to N -formyl-methionyl-leucyl-phenylalanine. These changes were abolished in cells that had been incubated with 2 micromolar cytochalasin D, an agent that disrupts cellular actin organization. A monoclonal antibody directed at the CD11-CD18 adhesive glycoprotein complex did not inhibit the increase in stiffness or retention in pores. These data suggest that neutrophil stiffening may be both necessary and sufficient for the retention that is observed. Hence, neutrophil sequestration in lung and other capillaries in the acute inflammatory process may be the result of increased stiffness stimulated by chemoattractants.
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Citations
Cites
Role of cell shape in growth control
Folkman, J., & Moscona, A. (1978) · Nature · doi:10.1038/273345a0 · Cited by 2,422
Cited by
Contribution of Neutrophils to Acute Lung Injury
Grommes, J., & Soehnlein, O. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00138 · Cited by 1,313
Mechanical models for living cells—a review
Lim, C. T., Zhou, E. H., & Quek, S. T. (2006) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.12.008 · Cited by 719
Rowat, A. C., Jaalouk, D. E., Zwerger, M., Ung, W. L., Eydelnant, I. A., Olins, D. E., Olins, A. L., Herrmann, H., Weitz, D. A., & Lammerding, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.441535 · Cited by 320
Tsai, M., Kita, A., Leach, J., Rounsevell, R., Huang, J. N., Moake, J., Ware, R. E., Fletcher, D. A., & Lam, W. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58753 · Cited by 297
Dose-Response Relationship to Inhaled Endotoxin in Normal Subjects
MICHEL, O., NAGY, A.-M., SCHROEVEN, M., DUCHATEAU, J., NÈVE, J., FONDU, P., & SERGYSELS, R. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.4.97-02002 · Cited by 284
Metadata
- Authors
- Worthen, G. S., Schwab, B., Elson, E. L., & Downey, G. P.
- Venue
- Science
- Published
- 1989-07-14
- Volume
- 245
- Issue
- 4914
- Pages
- 183-186
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988158019
- Cited by
- 597
- References
- 1
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mechanics of Stimulated Neutrophils: Cell Stiffening Induces Retention in Capillaries. https://app.cochat.ai/papers/10.1126/science.2749255
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- Worthen, G. S., Schwab, B., Elson, E. L., & Downey, G. P. (1989). Mechanics of Stimulated Neutrophils: Cell Stiffening Induces Retention in Capillaries. Science. https://doi.org/10.1126/science.2749255
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
