The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Periaqueductal Gray Matter Mediates Opiate-Induced Immunosuppression
Abstract
The periaqueductal gray matter of the mesencephalon (PAG) subserves a variety of diverse autonomic functions and also appears to be a site for opiate action in the induction of immunosuppression. Microinjections of morphine into the PAG, but not into other opiate receptor-containing neuroanatomical sites, result in a rapid suppression of natural killer (NK) cell activity. The NK cell suppression can be blocked by prior peripheral administration of the opiate antagonist naltrexone. These findings demonstrate that certain central actions of opiates that produce changes in NK cell function are mediated through opiate receptors in the PAG and identify a brain region involved in opiate regulation of immune function.
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Cites
Noradrenergic and peptidergic innervation of lymphoid tissue
Felten, D. L., Felten, S. Y., Carlson, S. L., Olschowka, J. A., & Livnat, S. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.2.755 · Cited by 1,025
Cited by
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Wrona, D. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.10.017 · Cited by 323
Roy, S., Ninkovic, J., Banerjee, S., Charboneau, R. G., Das, S., Dutta, R., Kirchner, V. A., Koodie, L., Ma, J., Meng, J., et al. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9292-5 · Cited by 309
The role of opioid receptors in immune system function
Eisenstein, T. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02904 · Cited by 286
Opioid Guidelines in the Management of Chronic Non-Cancer Pain
Manchikanti, L. (2006) · Pain Physician · doi:10.36076/ppj.2006/9/2 · Cited by 277
Metadata
- Authors
- Weber, R. J., & Pert, A.
- Venue
- Science
- Published
- 1989-07-14
- Volume
- 245
- Issue
- 4914
- Pages
- 188-190
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042837551
- Cited by
- 279
- References
- 1
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weber, R. J., & Pert, A. (1989). The Periaqueductal Gray Matter Mediates Opiate-Induced Immunosuppression. Science. https://doi.org/10.1126/science.2749256
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
