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A Protein-Counting Mechanism for Telomere Length Regulation in Yeast
Open accessAbstract
In the yeast Saccharomyces cerevisiae , telomere elongation is negatively regulated by the telomere repeat-binding protein Rap1p, such that a narrow length distribution of telomere repeat tracts is observed. This length regulation was shown to function independently of the orientation of the telomere repeats. The number of repeats at an individual telomere was reduced when hybrid proteins containing the Rap1p carboxyl terminus were targeted there by a heterologous DNA-binding domain. The extent of this telomere tract shortening was proportional to the number of targeted molecules, consistent with a feedback mechanism of telomere length regulation that can discriminate the precise number of Rap1p molecules bound to the chromosome end.
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“However, a strong common theme that has emerged is the likely involvement of a protein-counting mechanism in both systems (31, 44).”
From Control of Human Telomere Length by TRF1 and TRF2 (2000) · cites this paper as [31]
Citations
Cites
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
WATSON, J. D. (1972) · Nature New Biology · doi:10.1038/newbio239197a0 · Cited by 1,632
Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
Gottschling, D. E., Aparicio, O. M., Billington, B. L., & Zakian, V. A. (1990) · Cell · doi:10.1016/0092-8674(90)90141-z · Cited by 1,325
Greider, C. W. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.002005 · Cited by 1,032
Telomeres: Beginning to Understand the End
Zakian, V. A. (1995) · Science · doi:10.1126/science.270.5242.1601 · Cited by 859
TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase
Singer, M. S., & Gottschling, D. E. (1994) · Science · doi:10.1126/science.7545955 · Cited by 736
Chong, L., van Steensel, B., Broccoli, D., Erdjument‐Bromage, H., Hanish, J., Tempst, P., & de Lange, T. (1995) · Science · doi:10.1126/science.270.5242.1663 · Cited by 714
Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance
Nugent, C. I., Hughes, T., Lue, N. F., & Lundblad, V. (1996) · Science · doi:10.1126/science.274.5285.249 · Cited by 606
Moretti, P. M., Freeman, K., Coodly, L. R., & Shore, D. (1994) · Genes & Development · doi:10.1101/gad.8.19.2257 · Cited by 547
Self-citationYUDKIN, J. (1972) · Nature · doi:10.1038/239197a0 · Cited by 545
Research works printed but not linked: 11
- ibid. 51, 887 (1987);
- Harley C. B., Telomeres,, Blackburn E., Greider C., Eds. (Cold Spring Harbor Press, Plainview, NY, 1995247-263).
- Lustig A. J. and , Petes T. D., ibid. 83, 1398 (1986).
- Krauskopf A. and , Blackburn E. H., ibid. 383, 354 (1996);
- Buck S. thesis Columbia University (1996).
- Kyrion G., Boakye K. A., Lustig A. J., Mol. Cell. Biol. 12, 5159 (1992).
- Overexpression of the COOH-terminal half of Rap1p from a high-copy number plasmid was reported to cause telomere lengthening (5) [C. F. J. Hardy thesis Columbia University (1991)]. In our experiments the Gbd/Rap1 hybrid was expressed on a centromere plasmid by means of the RAP1 promoter which most likely explains its lack of effect on telomere length in the absence of UAS G sites.
- Chien C.-T., Buck S., Sternglanz R., Shore D., ibid.531.
- Grandin N. , Reed S. I. , Charbonneau M., Genes Dev., in press.
- Wotton D. and , Shore D., ibid., in press.
- van Steensel B. de Lange T. Nature in press.
Cited by
Sorted by citations
Items 301–400 of 522
Telomere tales: chromatin, telomerase and telomere function in Saccharomyces cerevisiae
Lowell, J. E., & Pillus, L. (1998) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050123 · Cited by 27
Dissociation of Telomere Dynamics from Telomerase Activity in Human Thyroid Cancer Cells
Jones, C. J., Soley, A., Skinner, J. W., Gupta, J., Haughton, M. F., Wyllie, F. S., Schlumberger, M. J., Bacchetti, S., & Wynford‐Thomas, D. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.3944 · Cited by 27
Edsö, J. R., Gustafsson, C., & Cohn, M. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-2 · Cited by 26
“It has been shown that the length of the telomere is determined by the number of Rap1 binding sites [8,9].”
BackgroundInfluentialHailemariam, S., Bona, P. D., Galletto, R., Hohl, M., Petrini, J. H. J., & Burgers, P. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011077 · Cited by 25
“1A) (20), leading to an increased repressive effect on telomere elongation.”
BackgroundThe multifunctional transcription factor Rap1 a regulator of yeast physiology
Tomar, R. S. (2016) · Frontiers in bioscience · doi:10.2741/4429 · Cited by 26
“length regulation (10), sub-telomeric gene silencing, HML”
A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres
Strecker, J., Stinus, S., Caballero, M. P., Szilard, R. K., Chang, M., & Durocher, D. (2017) · eLife · doi:10.7554/elife.23783 · Cited by 27
“limit the extension of long telomeres through the negative regulators Rif1 and Rif2 (Marcand et al., 1997; Levy and Blackburn, 2004; McGee et al., 2010; Hirano et al., 2009).”
BackgroundInfluentialRaymond, É., Sun, D., Izbicka, E., Mangold, G. L., Silvas, E., Windle, B. E., Sharma, S., Soda, H., Laurence, R., Davidson, K. K., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690526 · Cited by 28
“Convergent evidence leads to the hypothesi telomeric attrition could act as a cell division counter limiting proliferative somatic cell life span (Greider, 1993; Harrington e 1997; Marcand et al, 1997).”
BackgroundAnalysis of the RAP1 protein binding to homogeneous telomeric repeats in Saccharomyces castellii
Wahlin, J., & Cohn, M. (2002) · Yeast · doi:10.1002/yea.816 · Cited by 26
“The S. cerevisiae telomere length has been shown to be negatively regulated by Rap1p, in the range of 300 bp, by a mechanism of counting the number of Rap1p molecules (Marcand et al., 1997).”
BackgroundInfluentialSir3p Domains Involved in the Initiation of Telomeric Silencing in Saccharomyces cerevisiae
Park, Y., Hanish, J., & Lustig, A. J. (1998) · Genetics · doi:10.1093/genetics/150.3.977 · Cited by 26
Kaizer, H., Connelly, C. J., Bettridge, K. E., Viggiani, C. J., & Greider, C. W. (2015) · Genetics · doi:10.1534/genetics.115.177899 · Cited by 25
Cell‐cycle‐dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo‐like kinase
Nishiyama, A., Muraki, K., Saito, M., Ohsumi, K., Kishimoto, T., & Ishikawa, F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600964 · Cited by 25
“There is mounting evidence that telomerase activity is regulated in cis at individual telomeres by the number of associated telomeric-DNA-binding proteins (the proteincounting model) (Marcand et al, 1997).”
Kobayashi, S., Fukatsu, R., Kanoh, Y., Kakusho, N., Matsumoto, S., Chaen, S., & Masai, H. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00364-18 · Cited by 24
“Rif1, originally identified as a telomere binding factor in budding yeast (14, 15), has been shown to regulate transcriptional silencing and telomere length in concert with Rap1 (14, 16, 17).”
TERRA and Telomere Maintenance in the Yeast Saccharomyces cerevisiae
Zeinoun, B., Teixeira, M. T., & Barascu, A. (2023) · Genes · doi:10.3390/genes14030618 · Cited by 26
“This is due to the increased occupancy of Rap1 molecules at longer telomeres inhibiting telomerase [71].”
BackgroundBah, A., Gilson, É., & Wellinger, R. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220186 · Cited by 23
Telomeres and Essential Hypertension
Aviv, A. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00202-7 · Cited by 24
Telomere Structure, Replication and Length Maintenance
Muniyappa, K., & Kironmai, K. M. (1998) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409239891204242 · Cited by 23
Obodo, U. C., Epum, E. A., Platts, M. H., Seloff, J., Dahlson, N., Velkovsky, S. M., Paul, S. R., & Friedman, K. L. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00095-16 · Cited by 22
Minishelterins separate telomere length regulation and end protection in fission yeastPreprint
Pan, L., Hildebrand, K., Stutz, C., Thomä, N. H., & Baumann, P. (2015) · Genes & Development · doi:10.1101/gad.261123.115 · Cited by 23
“This effect was rescued by supplementation with an endogenous copy of Taz1, consistent with Taz1 functioning as part of a counting mechanism as described for Rap1 in budding yeast (Marcand et al. 1997).”
BackgroundPossible mechanisms for the regulation of telomere length
Kowald, A. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1305 · Cited by 23
Double-stranded telomeric DNA binding proteins: Diversity matters
Červenák, F., Juríková, K., Sepšiová, R., Neboháčová, M., Nosek, J., & Tomáška, Ľ. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1356511 · Cited by 23
Telomerase recruitment to telomeres
Stern, J. L., & Bryan, T. M. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167810 · Cited by 22
“Tethering the telomere protein Rap1p to the telomere resulted in a reduction of telomere tract length in a manner that depended on the number of Rap1p molecules (Marcand et al., 1997).”
Underwood, D. H., Carroll, C., & McEachern, M. J. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.369-384.2004 · Cited by 22
“cerevisiae, Rap1p has been shown to be a negative regulator of telomere length (34).”
Afrin, M., Kishmiri, H., Sandhu, R. S., Rabbani, M. A. G., & Li, B. (2020) · mSphere · doi:10.1128/msphere.00027-20 · Cited by 18
Bechard, L. H., BÜTÜNER, B. D., Peterson, G. J., McRae, W., Topcu, Z., & McEachern, M. J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00423-08 · Cited by 21
“lactis through its ability to bind doublestranded telomeric repeats (37, 44).”
BackgroundPiqueret‐Stephan, L., Ricoul, M., Hempel, W. M., & Sabatier, L. (2016) · Scientific Reports · doi:10.1038/srep32510 · Cited by 22
Telomeric Position Effect in Drosophila Melanogaster Reflects a Telomere Length Control Mechanism
Mason, J. M., Konev, A. Y., & Biessmann, H. (2003) · Genetica · doi:10.1023/a:1022925003172 · Cited by 21
“The underlying idea that the structure and the number of repeat units at a telomere modulates telomere elongation parallels the model proposed for telomere elongation in the yeast S. cerevisiae .I t was found that yeast cells count the number of Rap1p molecules that are associated with telomeric TG1–3 repeats, and wit…”
BackgroundYeast telomerase is specialized for C/A-rich RNA templates
Förstemann, K. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg261 · Cited by 22
Telomere-length regulation in inter-ecotype crosses of Arabidopsis
Maillet, G., White, C. I., & Gallego, M. E. (2006) · Plant Molecular Biology · doi:10.1007/s11103-006-9061-7 · Cited by 21
“These observations are consistent with the protein-counting model for telomere-length control (Marcand et al. 1997).”
BackgroundResultInfluentialAklilu, B. B., Peurois, F., Saintomé, C., Culligan, K. M., Kobbe, D., Leasure, C. S., Chung, M., Cattoor, M., Lynch, R., Sampson, L., et al. (2020) · Genetics · doi:10.1534/genetics.120.303222 · Cited by 19
Misino, S., Busch, A., Wagner, C. B., Bento, F., & Luke, B. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac1125 · Cited by 23
Cohn, M., Liti, G., & Barton, D. B. H. (2007) · Springer eBooks · doi:10.1007/4735_108 · Cited by 19
Regulation of Telomere Length by an N-Terminal Region of the Yeast Telomerase Reverse Transcriptase
Ji, H., Platts, M. H., Dharamsi, L. M., & Friedman, K. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.20.9103-9114.2005 · Cited by 20
Making the most of a little: dosage effects in eukaryotic telomere length maintenance
Harrington, L. A. (2005) · Chromosome Research · doi:10.1007/s10577-005-0994-5 · Cited by 20
“These data support a previously developed model that the propensity to elongate a given telomere is inversely proportional to its length ( Marcand et al. 1997a, 1997b, Wotton & Shore 1997, Ray & Runge 1998, 1999a, 1999b, Li & de Lange 2003).”
BackgroundMethodTERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends
Bettin, N., Querido, E., Gialdini, I., Grupelli, G. P., Goretti, E., Cantarelli, M., Andolfato, M., Soror, E., Sontacchi, A., Juríková, K., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk4387 · Cited by 20
Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication
Goto, G. H., Zencir, S., Hirano, Y., Ogi, H., Ivessa, A., & Sugimoto, K. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005283 · Cited by 18
“Instead, telomerase-dependent telomere addition occurs at DNA ends with telomeric TG repeat sequence nearby [25,40], a phenomenon which is referred to as “telomere healing” (Fig 1B).”
BackgroundInfluentialPeggion, C., Lopreiato, R., Casanova, E., Ruzzene, M., Facchin, S., Pinna, L. A., Carignani, G., & Sartori, G. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06721.x · Cited by 19
Telomeres in Drag: dressing as DNA damage to engage telomerase
Rog, O., & Cooper, J. P. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.01.011 · Cited by 18
Characterization of the DNA Binding Features of Saccharomyces castellii Cdc13p
Edsö, J. R., Astromskas, E., & Cohn, M. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.10.078 · Cited by 19
Lundblad, V. (2003) · Nature · doi:10.1038/423926a · Cited by 19
Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers
Hsieh, M., Tsai, C.-H., Lin, C., Li, T., Hung, T.-W., Chang, L.-T., Hsin, L., & Teng, S. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1783-0 · Cited by 20
The role of shelterin in maintaining telomere integrity
Longhese, M. P. (2011) · Frontiers in bioscience · doi:10.2741/4014 · Cited by 20
“It was proposed that telomere length regulation is achieved through a negative feedback loop, where the telomeric DNA is bound by an inhibitor of telomerase in an amount proportional to telomere length (149).”
BackgroundNew Function of CDC13 in Positive Telomere Length Regulation
Meier, B., Driller, L., Jaklin, S., & Feldmann, H. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4233-4245.2001 · Cited by 18
“meric DNA and regulates telomerase activity (37, 38).”
BackgroundMuñoz‐Jordán, J. L. (2001) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(01)00259-6 · Cited by 18
“High expression of Rap1, Taz1, TRF1, or TRF2, however, results in telomere shortening, suggesting a common role as negative regulators of telomerase [4–7].”
BackgroundResultTelomere maintenance and the DNA damage response: a paradoxical alliance
Harman, A., & Bryan, T. M. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1472906 · Cited by 19
“…frameworks for how this achieved; for example, the “ protein counting model ” postulates that the overall abundance of shelterin proteins at telomeres provides a negative regulatory signal for telomerase recruitment and/or extension (Marcand et al., 1997; Smogorzewska and de Lange, 2004).”
BackgroundThe DNA-Binding Domain of Yeast Rap1 Interacts with Double-Stranded DNA in Multiple Binding Modes
Feldmann, E. A., & Galletto, R. (2014) · Biochemistry · doi:10.1021/bi501049b · Cited by 16
Shakirov, E. V., Salzberg, S. L., Alam, M., & Shippen, D. E. (2008) · Tropical Plant Biology · doi:10.1007/s12042-008-9018-x · Cited by 16
“In yeast and human cells, the number of these proteins bound to the telomere is precisely measured, and this information is used to help determine whether a particular telomere tract should be extended by telomerase [26, 33].”
Dynamics of telomeric chromatin at the crossroads of aging and cancer
Ye, J., Wu, Y., & Gilson, É. (2010) · Essays in Biochemistry · doi:10.1042/bse0480147 · Cited by 15
“mechanism analogous to that described in budding yeast [86,93].”
BackgroundInduction of Global Stress Response in Saccharomyces cerevisiae Cells Lacking Telomerase
Teng, S., Epstein, C. B., Tsai, Y.-L., Cheng, H.-W., Chen, H.-L., & Lin, J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6509 · Cited by 17
Yeast Est2p Affects Telomere Length by Influencing Association of Rap1p with Telomeric Chromatin
Ji, H., Adkins, C. J., Cartwright, B. R., & Friedman, K. L. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01648-07 · Cited by 16
“ately shortens the TG1-3 tract in cis (25, 26).”
BackgroundTetrahymena Mutants With Short Telomeres
Ahmed, S. C., Hong, S., Niu, L., & Henderson, E. R. (1998) · Genetics · doi:10.1093/genetics/150.2.643 · Cited by 16
Gao, H., Moss, D. L., Parke, C., Tatum, D. M., & Lustig, A. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088633 · Cited by 15
“yeast and human cells [14–17].”
Rubinstein, L., Ungar, L., Harari, Y., Babin, V., Ben‐Aroya, S., Merenyi, G., Marjavaara, L., Chabes, A., & Kupiec, M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku267 · Cited by 15
Li, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.699639 · Cited by 14
Telomere shortening triggers a feedback loop to enhance end protection
Yang, C.-W., Tseng, S., Yu, C., Chung, C., Chang, C.-Y., Pobiega, S., & Teng, S. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx503 · Cited by 19
Aging chromosome telomeres: parallel studies with terminal repeat and telomere associated DNA probes
BENN, P. A. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00099-7 · Cited by 15
The Telomere and Telomerase: How do they Interact?
Blackburn, E. H., Bhattacharyya, A., Gilley, D. P., Kirk, K. E., Krauskopf, A., McEachern, M. J., Prescott, J. C., & Ware, T. L. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515433.ch2 · Cited by 15
Organization and expression of human telomere repeat binding factor genes
Young, A. C., Chavez, M., Giambernardi, T. A., Mattern, V. L., McGill, J. R., Harris, J. M., Sarosdy, M. F., Patel, P., & Sakaguchi, A. Y. (1997) · Somatic Cell and Molecular Genetics · doi:10.1007/bf02674418 · Cited by 15
Telomere length regulation in budding yeasts
Malyavko, A. N., Parfenova, Y. Y., Zvereva, M. I., & Донцова, О. А. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.05.049 · Cited by 14
“All these results fit with the protein-counting model which was proposed more than a decade ago [60] to explain the inhibitory”
ResultRegulation of homologous recombination at telomeres in budding yeast
Eckert‐Boulet, N., & Lisby, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.05.037 · Cited by 14
“The longer the double-stranded telomeric DNA, the greater the amount of Rapl bound to it, resulting in inhibition of telomerase activity [33,46].”
BackgroundCharacterization and expression analysis of the tomato telomere-binding protein LeTBP1
Moriguchi, R., Kanahama, K., & Kanayama, Y. (2006) · Plant Science · doi:10.1016/j.plantsci.2006.03.010 · Cited by 14
Lin, Y., Chang, C., Wong, C., & Teng, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008224 · Cited by 15
“Sugino) was used to create the pol2-4 mutant in YPH499 background by the method previously described [3].”
MethodThe Transcriptional Repressor Activator Protein Rap1p Is a Direct Regulator of TATA-binding Protein
Bendjennat, M., & Weil, P. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709436200 · Cited by 14
Bonetti, D., Rinaldi, C., Vertemara, J., Notaro, M., Pizzul, P., Tisi, R., Zampella, G., & Longhese, M. P. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1203 · Cited by 15
“Rap1 directly binds Rif2 and Rif1 proteins to form a protein complex that negatively controls telomerase-mediated telomere elongation (28,35,61).”
Limited TTP supply affects telomere length regulation in a telomerase-independent fashion
Toussaint, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki219 · Cited by 14
Telomerase regulation by the Pif1 helicase: a length-dependent effect?
Stinus, S., Paeschke, K., & Chang, M. (2017) · Current Genetics · doi:10.1007/s00294-017-0768-6 · Cited by 16
“According to the protein-counting model (Marcand et al. 1997), telomere-bound Rap1 increases proportionally with telomere length, preventing telomerase from extending the longer telomeres, thereby providing a mechanism to maintain telomere length homeostasis.”
BackgroundTwo telomerase reverse transcriptases (TERTs) expressed in Candida albicans
Metz, A. M., Love, R. A., Strobel, G. A., & Long, D. M. (2001) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20010021 · Cited by 14
A mechanism for telomere-specific telomere length regulation
Teplitz, G. M., Pasquier, E., Bonnell, E., Laurentiis, E. D., Bartle, L., Lucier, J., St-Laurent, G., Dawson, D. S., & Wellinger, R. J. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1457 · Cited by 17
“This mechanism also explains the previously puzzling observation that tethering of the Sir4 protein to a specific telomere will cause lengthening exclusively of that particular telomere in cis [ 52 ].”
Gustafsson, C., Edsö, J. R., & Cohn, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.300517 · Cited by 13
tRNA ADENOSINE DEAMINASE 3 is required for telomere maintenance in Arabidopsis thaliana
Bose, S., Suescún, A. V., Song, J., Castillo-González, C., Aklilu, B. B., Branham, E. M., Lynch, R., & Shippen, D. E. (2020) · Plant Cell Reports · doi:10.1007/s00299-020-02594-0 · Cited by 13
Martin, H., Doumic, M., Teixeira, M. T., & Xu, Z. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00693-3 · Cited by 13
Wang, J., Zhang, H., Shibar, M. A., Willard, B. B., Ray, A., & Runge, K. W. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.03.001 · Cited by 12
Gurevich, R., Smolikov, S., Maddar, H., & Krauskopf, A. (2003) · Molecular Genetics and Genomics · doi:10.1007/s00438-002-0788-9 · Cited by 13
“…to regulate telomere length through a process involving the formation of a complex between the telomere-bound Rap1p and Rif1p /Rif2p, while the more internal telomeric domain participates in silencing by tethering a complex of Sir proteins, again via telomere-bound Rap1p (Marcand et al. 1997).”
BackgroundEdsö, J. R., Tati, R., & Cohn, M. (2008) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2008.00431.x · Cited by 13
Mammalian artificial chromosomes — vectors for somatic gene therapy
Ascenzioni, F., Donini, P., & Lipps, H. J. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)00323-6 · Cited by 13
Telomeres, not the end of the story
Gotta, M., & Cockell, M. M. (1997) · BioEssays · doi:10.1002/bies.950190503 · Cited by 13
Computing the Length of the Shortest Telomere in the Nucleus
Duc, K. D., & Holcman, D. (2013) · Physical Review Letters · doi:10.1103/physrevlett.111.228104 · Cited by 11
Domenico, E. G. D., Auriche, C., Viscardi, V., Longhese, M. P., Gilson, É., & Ascenzioni, F. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.10.005 · Cited by 12
Yeast telomerase appears to frequently copy the entire template in vivo
Ray, A. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.2382 · Cited by 12
Telomerase Regulation at the Telomere
Loayza, D., & de Lange, T. (2004) · Cell · doi:10.1016/s0092-8674(04)00409-x · Cited by 12
Possemato, R., Timmons, J. C., Bauerlein, E. L., Wada, N., Baldwin, A. E., Masutomi, K., & Hahn, W. C. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0070 · Cited by 13
Azad, G. K., Singh, V., Baranwal, S., Thakare, M. J., & Tomar, R. S. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.11.024 · Cited by 11
Expression of Subtelomeric lncRNAs Links Telomeres Dynamics to RNA Decay in S. cerevisiae
Kwapisz, M., Ruault, M., van Dijk, E., Gourvennec, S., Descrimes, M., Taddei, A., & Morillon, A. (2015) · Non-Coding RNA · doi:10.3390/ncrna1020094 · Cited by 10
“Rap1p-interacting factors - Rif1p and Rif2p bind to the C-terminal domain and inhibit telomerase activity and telomere lengthening [22].”
BackgroundBudding yeast with human telomeres: A puzzling structure
Auriche, C., Domenico, E. G. D., & Ascenzioni, F. (2007) · Biochimie · doi:10.1016/j.biochi.2007.09.009 · Cited by 12
Telomeres and telomerase: From basic research to clinical applications
Ségal-Bendirdjian, E., & Gilson, É. (2007) · Biochimie · doi:10.1016/j.biochi.2007.10.003 · Cited by 11
QTL Mapping and Candidate Gene Analysis of Telomere Length Control Factors in Maize (Zea maysL.)
Brown, A. N., Lauter, N., Vera, D. L., McLaughlin-Large, K. A., Steele, T. M., Fredette, N. C., & Bass, H. W. (2011) · G3 Genes Genomes Genetics · doi:10.1534/g3.111.000703 · Cited by 10
“…regulation involves a negative-feedback or telomere protein-counting mechanism in which the length of the telomere and the abundance of the associated proteins produce a cis -acting negative feedback signal for telomerase-mediated extension (Marcand et al. 1997; Van Steensel and De Lange 1997).”
BackgroundPulse Detecting Genetic Circuit – A New Design Approach
Noman, N., Inniss, M. C., Iba, H., & Way, J. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167162 · Cited by 11
Telomere Shortening by Cisplatin in Yeast Nucleotide Excision Repair Mutant
Ishii, K., Yang, W.-L., Cvijic, M. E., Kikuchi, Y., Nagata, I., & Chin, K. (2000) · Experimental Cell Research · doi:10.1006/excr.1999.4777 · Cited by 12
Different means to common ends
Shore, D. (1997) · Nature · doi:10.1038/385676a0 · Cited by 11
Self-citationAssociations of Rap1 with Cell Wall Integrity, Biofilm Formation, and Virulence in Candida albicans
Wang, W., Lai, T.-X., Wu, Y., Chen, Z.-T., Tseng, K., & Lan, C. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.03285-22 · Cited by 11
The origin of oxidized guanine resolves the puzzle of oxidation-induced telomere-length alterations
Sarkar, J., & Liu, Y. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3332 · Cited by 10
Sayed, M. E., Cheng, A., Yadav, G. P., Ludlow, A. T., Shay, J. W., Wright, W. E., & Jiang, Q. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.007234 · Cited by 10
A new look at the challenging world of tandem repeats
Fonzo, V. D., Bersani, E., Aluffi-Pentini, F., & Parisi, V. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.0945 · Cited by 10
Piening, B., Huang, D., & Paulovich, A. G. (2013) · Genetics · doi:10.1534/genetics.113.149849 · Cited by 9
Wang, Z.-R., Guo, L., Chen, L., & McEachern, M. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00528-09 · Cited by 9
“This region of the telomeric repeat lies within the binding site for the Rap1 protein, a key factor in telomeric length regulation in yeast (20, 23).”
BackgroundRif1 regulates telomere length through conserved HEAT repeats
Shubin, C. B., Mayangsari, R., Swett, A. D., & Greider, C. W. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab206 · Cited by 9
Shepelev, N. M., Донцова, О. А., & Rubtsova, M. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24055027 · Cited by 9
“Together, they form a negative feedback loop that regulates telomere elongation in a length-dependent manner [89,90].”
BackgroundEffects of lead and selenium on yeast(Saccharomyces cerevisiae)telomere
Cui, Q., & Tang, C. (2000) · Journal of Environmental Science and Health Part A · doi:10.1080/10934520009377062 · Cited by 8
Venditti, S., Vega-Palas, M. A., Stefano, G. D., & Mauro, E. D. (1999) · Molecular and General Genetics MGG · doi:10.1007/s004380051095 · Cited by 9
“Telomeric elongation is negatively regulated by the telomere repeat-binding Rap1p (Marcand et al. 1997), so that a narrow length distribution of telomere repeat length is usually observed.”
BackgroundTotally Mutant Telomeres: Single-Step Mutagenesis of Tandem Repeat DNA Sequences
Underwood, D. H., & McEachern, M. J. (2001) · BioTechniques · doi:10.2144/01305bm02 · Cited by 9
Molecular mechanisms regulating telomerase activity
Liu, J. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08003-8 · Cited by 9
Metadata
- Authors
- Marcand, S., Gilson, E., & Shore, D.
- Affiliations
- École Normale Supérieure de Lyon (FR)
- E. Gilson, Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure de Lyon, UMR49 CNRS/ENSL, 69364 Lyon Cédex 07, France.
- University of Geneva (CH)
- Corresponding author
- Marcand, Stéphane
- Shore, David
- Venue
- Science
- Published
- 1997-02-14
- Volume
- 275
- Issue
- 5302
- Pages
- 986-990
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978002329
- Cited by
- 524
- References
- 38
- Citations by year
- 2026: 10 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 14 · 2020: 5 · 2019: 17 · 2018: 10 · 2017: 12 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 14 · 2012: 10
- FWCI
- 23.60
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (5r01gm040094-09)
- National Institute of General Medical Sciences (GM 40094)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- telomere length regulation, Rap1p, feedback regulation, protein-DNA interactions, telomere elongation, Saccharomyces cerevisiae, telomere shortening
- MeSH terms
- Binding Sites, Fungal Proteins, Genetic Markers, Mutation, Saccharomyces cerevisiae, Transformation, Genetic, Chromosomes, Fungal, Gene Expression Regulation, Fungal, Telomere, Telomerase, GTP-Binding Proteins, rap GTP-Binding Proteins
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