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Cited by 524Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin Dynamics

The DOI matches its Crossref record; 36 of the 38 references it cites were found in a registry or an index.

A Protein-Counting Mechanism for Telomere Length Regulation in Yeast

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Marcand, Stéphane, Gilson, Eric, Shore, David·1997·Science
DOI 10.1126/science.275.5302.986
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Abstract

In the yeast Saccharomyces cerevisiae , telomere elongation is negatively regulated by the telomere repeat-binding protein Rap1p, such that a narrow length distribution of telomere repeat tracts is observed. This length regulation was shown to function independently of the orientation of the telomere repeats. The number of repeats at an individual telomere was reduced when hybrid proteins containing the Rap1p carboxyl terminus were targeted there by a heterologous DNA-binding domain. The extent of this telomere tract shortening was proportional to the number of targeted molecules, consistent with a feedback mechanism of telomere length regulation that can discriminate the precise number of Rap1p molecules bound to the chromosome end.

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  1. ibid. 51, 887 (1987);
  2. Harley C. B., Telomeres,, Blackburn E., Greider C., Eds. (Cold Spring Harbor Press, Plainview, NY, 1995247-263).
  3. Lustig A. J. and , Petes T. D., ibid. 83, 1398 (1986).
  4. Krauskopf A. and , Blackburn E. H., ibid. 383, 354 (1996);
  5. Buck S. thesis Columbia University (1996).
  6. Kyrion G., Boakye K. A., Lustig A. J., Mol. Cell. Biol. 12, 5159 (1992).
  7. Overexpression of the COOH-terminal half of Rap1p from a high-copy number plasmid was reported to cause telomere lengthening (5) [C. F. J. Hardy thesis Columbia University (1991)]. In our experiments the Gbd/Rap1 hybrid was expressed on a centromere plasmid by means of the RAP1 promoter which most likely explains its lack of effect on telomere length in the absence of UAS G sites.
  8. Chien C.-T., Buck S., Sternglanz R., Shore D., ibid.531.
  9. Grandin N. , Reed S. I. , Charbonneau M., Genes Dev., in press.
  10. Wotton D. and , Shore D., ibid., in press.
  11. van Steensel B. de Lange T. Nature in press.

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Metadata

Authors
Marcand, S., Gilson, E., & Shore, D.
Affiliations
  • École Normale Supérieure de Lyon (FR)
  • E. Gilson, Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure de Lyon, UMR49 CNRS/ENSL, 69364 Lyon Cédex 07, France.
  • University of Geneva (CH)
Corresponding author
  • Marcand, Stéphane
  • Shore, David
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1997-02-14
Volume
275
Issue
5302
Pages
986-990
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.275.5302.986
OpenAlex
W1978002329
Cited by
524
References
38
Citations by year
2026: 10 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 14 · 2020: 5 · 2019: 17 · 2018: 10 · 2017: 12 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 14 · 2012: 10
FWCI
23.60
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • National Institutes of Health (5r01gm040094-09)
  • National Institute of General Medical Sciences (GM 40094)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
telomere length regulation, Rap1p, feedback regulation, protein-DNA interactions, telomere elongation, Saccharomyces cerevisiae, telomere shortening
MeSH terms
Binding Sites, Fungal Proteins, Genetic Markers, Mutation, Saccharomyces cerevisiae, Transformation, Genetic, Chromosomes, Fungal, Gene Expression Regulation, Fungal, Telomere, Telomerase, GTP-Binding Proteins, rap GTP-Binding Proteins

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