The DOI matches its Crossref record.
Direct Measurement of Single-Molecule Diffusion and Photodecomposition in Free Solution
Abstract
Continuous monitoring of submillisecond free-solution dynamics of individual rhodamine-6G molecules and 30-base single-stranded DNA tagged with rhodamine was achieved. Fluorescence images were recorded from the same set of isolated molecules excited either through the evanescent field at the quartz-liquid interface or as a thin layer of solution defined by micron-sized wires, giving diffraction-limited resolution of interconnected attoliter volume elements. The single-molecule diffusion coefficients were smaller and the unimolecular photodecomposition lifetimes were longer for the dye-DNA covalent complex as compared with those of the dye molecule itself. Unlike bulk studies, stochastic behavior was found for individual molecules of each type, and smaller diffusion coefficients were observed.
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Cited by
Toward a Glucose Biosensor Based on Surface-Enhanced Raman Scattering
Shafer-Peltier, K. E., Haynes, C. L., Glucksberg, M. R., & Van Duyne, R. P. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028255v · Cited by 653
Yonzon, C. R., Haynes, C. L., Zhang, X., Walsh, & Van Duyne, R. P. (2004) · Analytical Chemistry · doi:10.1021/ac035134k · Cited by 376
Metadata
- Authors
- Xu, X.-H., & Yeung, E. S.
- Venue
- Science
- Published
- 1997-02-21
- Volume
- 275
- Issue
- 5303
- Pages
- 1106-1109
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005082979
- Cited by
- 339
- References
- 0
- FWCI
- 18.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, X.-H., & Yeung, E. S. (1997). Direct Measurement of Single-Molecule Diffusion and Photodecomposition in Free Solution. Science. https://doi.org/10.1126/science.275.5303.1106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
