The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death
Abstract
Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-x L (a member of the Bcl-2 family of cell death regulators) were both found to interact with and inhibit the function of CED-4. In addition, analysis revealed that CED-4 can simultaneously interact with CED-3 and its mammalian counterparts interleukin-1β-converting enzyme (ICE) and FLICE. Thus, CED-4 plays a central role in the cell death pathway, biochemically linking CED-9 and the Bcl-2 family to CED-3 and the ICE family of pro-apoptotic cysteine proteases.
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Cites
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Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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Genetic control of programmed cell death in the nematode C. elegans
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Cited by
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Self-citationZou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145
Two CD95 (APO‐1/Fas) signaling pathways
Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K., Krammer, P. H., & Peter, M. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1675 · Cited by 3,000
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,760
Metadata
- Authors
- Chinnaiyan, A. M., O'Rourke, K., Lane, B. R., & Dixit, V. M.
- Venue
- Science
- Published
- 1997-02-21
- Volume
- 275
- Issue
- 5303
- Pages
- 1122-1126
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068240610
- Cited by
- 633
- References
- 3
- FWCI
- 42.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chinnaiyan, A. M., O'Rourke, K., Lane, B. R., & Dixit, V. M. (1997). Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death. Science. https://doi.org/10.1126/science.275.5303.1122
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