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Requirement of the DEAD-Box Protein Ded1p for Messenger RNA Translation
Abstract
The DED1 gene, which encodes a putative RNA helicase, has been implicated in nuclear pre-messenger RNA splicing in the yeast Saccharomyces cerevisiae . It is shown here by genetic and biochemical analysis that translation, rather than splicing, is severely impaired in two newly isolated ded1 conditional mutants. Preliminary evidence suggests that the protein Ded1p may be required for the initiation step of translation, as is the distinct DEAD-box protein, eukaryotic initiation factor 4A (eIF4A). The DED1 gene could be functionally replaced by a mouse homolog, PL10 , which suggests that the function of Ded1p in translation is evolutionarily conserved.
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Cited by
The mechanism of eukaryotic translation initiation and principles of its regulation
Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2838 · Cited by 2,759
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
Gingras, A.-C., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,121
Initiation of translation in prokaryotes and eukaryotes
Kozak, M. (1999) · Gene · doi:10.1016/s0378-1119(99)00210-3 · Cited by 1,364
Functional Coherence of the Human Y Chromosome
Lahn, B. T., & Page, D. C. (1997) · Science · doi:10.1126/science.278.5338.675 · Cited by 803
The Scanning Mechanism of Eukaryotic Translation Initiation
Hinnebusch, A. G. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035802 · Cited by 798
Metadata
- Authors
- Chuang, R.-Y., Weaver, P. L., Liu, Z., & Chang, T.-H.
- Venue
- Science
- Published
- 1997-03-07
- Volume
- 275
- Issue
- 5305
- Pages
- 1468-1471
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085795760
- Cited by
- 363
- References
- 0
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chuang, R.-Y., Weaver, P. L., Liu, Z., & Chang, T.-H. (1997). Requirement of the DEAD-Box Protein Ded1p for Messenger RNA Translation. Science. https://doi.org/10.1126/science.275.5305.1468
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