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Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis

Evangelista, Marie, Blundell, Kelly, Longtine, Mark S., Chow, Clinton J., Adames, Neil, Pringle, John R., Peter, Matthias, Boone, Charles·1997·Science

Abstract

The Saccharomyces cerevisiae BNI1 gene product (Bni1p) is a member of the formin family of proteins, which participate in cell polarization, cytokinesis, and vertebrate limb formation. During mating pheromone response, bni1 mutants showed defects both in polarized morphogenesis and in reorganization of the underlying actin cytoskeleton. In two-hybrid experiments, Bni1p formed complexes with the activated form of the Rho-related guanosine triphosphatase Cdc42p, with actin, and with two actin-associated proteins, profilin and Bud6p (Aip3p). Both Bni1p and Bud6p (like Cdc42p and actin) localized to the tips of mating projections. Bni1p may function as a Cdc42p target that links the pheromone response pathway to the actin cytoskeleton.

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Metadata

Authors
Evangelista, M., Blundell, K., Longtine, M. S., Chow, C. J., Adames, N., Pringle, J. R., Peter, M., & Boone, C.
Venue
Science
Published
1997-04-04
Volume
276
Issue
5309
Pages
118-122
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2019125570
Cited by
647
References
0
FWCI
17.44
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis. https://app.cochat.ai/papers/10.1126/science.276.5309.118
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Evangelista, M., Blundell, K., Longtine, M. S., Chow, C. J., Adames, N., Pringle, J. R., Peter, M., & Boone, C. (1997). Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis. Science. https://doi.org/10.1126/science.276.5309.118

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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