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Crystal Structure of Human BPI and Two Bound Phospholipids at 2.4 Angstrom Resolution
Abstract
Bactericidal/permeability-increasing protein (BPI), a potent antimicrobial protein of 456 residues, binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria. At a resolution of 2.4 angstroms, the crystal structure of human BPI shows a boomerang-shaped molecule formed by two similar domains. Two apolar pockets on the concave surface of the boomerang each bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide. As a model for the related plasma lipid transfer proteins, BPI illuminates a mechanism of lipid transfer for this protein family.
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Cites
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Cited by
Canny, G., Levy, O., Furuta, G. T., Narravula-Alipati, S., Sisson, R. B., Serhan, C. N., & Colgan, S. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052533799 · Cited by 295
Youn, J. H., Oh, Y. J., Kim, E. S., Choi, J. E., & Shin, J.-S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.5067 · Cited by 281
Kopec, K. O., Alva, V., & Lupas, A. N. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq326 · Cited by 212
Inhibition of Angiogenesis by Aβ Peptides
Paris, D., Townsend, K., Quadros, A., Humphrey, J., Sun, J., Brem, S., Wotoczek-Obadia, M., DelleDonne, A., Patel, N., Obregon, D. F., et al. (2004) · Angiogenesis · doi:10.1023/b:agen.0000037335.17717.bf · Cited by 148
Molecular Pathways Underlying Cholesterol Homeostasis
Afonso, M. S., Machado, R. M., Lavrador, M., Quintao, E. C. R., Moore, K., & Lottenberg, A. (2018) · Nutrients · doi:10.3390/nu10060760 · Cited by 138
Metadata
- Authors
- Beamer, L. J., Carroll, S. F., & Eisenberg, D.
- Venue
- Science
- Published
- 1997-06-20
- Volume
- 276
- Issue
- 5320
- Pages
- 1861-1864
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013313335
- Cited by
- 356
- References
- 1
- FWCI
- 18.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beamer, L. J., Carroll, S. F., & Eisenberg, D. (1997). Crystal Structure of Human BPI and Two Bound Phospholipids at 2.4 Angstrom Resolution. Science. https://doi.org/10.1126/science.276.5320.1861
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
