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Molecular Pathways Underlying Cholesterol Homeostasis

Afonso, Milessa Silva, Machado, Roberta Marcondes, Lavrador, Maria, Quintao, Eder Carlos Rocha, Moore, Kathryn, Lottenberg, Ana·2018·Nutrients
DOI 10.3390/nu10060760
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Abstract

Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis is crucial to maintaining proper cellular functioning. It is well documented that high plasma cholesterol concentration increases the risk of atherosclerotic heart disease. In the last decades, several studies have investigated the association of plasma cholesterol concentrations and the risk of cardiovascular diseases as well as the signaling pathways involved in cholesterol homeostasis. Here, we present an overview of several mechanisms involved in intestinal cholesterol absorption, the regulation of cholesterol synthesis and uptake. We also discuss the importance of reverse cholesterol transport and transintestinal cholesterol transport to maintain cholesterol homeostasis and prevent atherosclerosis development. Additionally, we discuss the influence of dietary cholesterol on plasma cholesterol concentration and the new recommendations for cholesterol intake in a context of a healthy dietary pattern.

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  • Cholesterol accumulation can trigger compensatory regulatory mechanisms, including reducing cholesterol synthesis and enhancing bile acid synthesis, to eliminate high cholesterol levels and attempt to return the liver to a steady state.

    “In general, cholesterol accumulation can trigger compensatory regulatory mechanisms, including reducing cholesterol synthesis and enhancing bile acid synthesis, to eliminate high cholesterol levels and attempt to return the liver to a steady state.85–88”

    From EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis (2025) · cites this paper as [88]

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Metadata

Authors
Afonso, M. S., Machado, R. M., Lavrador, M., Quintao, E. C. R., Moore, K., & Lottenberg, A.
Affiliations
  • Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
  • Laboratorio de Lipides (LIM 10), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP 05403-000, Brazil
Venue
Nutrients
Publisher
MDPI AG
Published
2018-06-13
Volume
10
Issue
6
Pages
760
ISSN
2072-6643
DOI
10.3390/nu10060760
Cited by
138
References
8
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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