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Dynamic Molecular Combing: Stretching the Whole Human Genome for High-Resolution Studies
Abstract
DNA in amounts representative of hundreds of eukaryotic genomes was extended on silanized surfaces by dynamic molecular combing. The precise measurement of hybridized DNA probes was achieved directly without requiring normalization. This approach was validated with the high-resolution mapping of cosmid contigs on a yeast artificial chromosome (YAC) within yeast genomic DNA. It was extended to human genomic DNA for precise measurements ranging from 7 to 150 kilobases, of gaps within a contig, and of microdeletions in the tuberous sclerosis 2 gene on patients' DNA. The simplicity, reproducibility, and precision of this approach makes it a powerful tool for a variety of genomic studies.
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Cited by
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Qu, X., Wu, D., Mets, L., & Scherer, N. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402155101 · Cited by 304
UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages
Greinert, R., Volkmer, B., Henning, S., Breitbart, E. W., Greulich, K. O., Cardoso, M. C., & Rapp, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks824 · Cited by 146
Human ribosomal RNA gene arrays display a broad range of palindromic structures
Caburet, S., Conti, C., Schurra, C., Lebofsky, R., Edelstein, S. J., & Bensimon, A. (2005) · Genome Research · doi:10.1101/gr.3970105 · Cited by 143
Self-citationMolecular genetics of 22q11.2 deletion syndrome
Morrow, B. E., McDonald‐McGinn, D. M., Emanuel, B. S., Vermeesch, J. R., & Scambler, P. J. (2018) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.40504 · Cited by 137
Carpenter, D., Dhar, S., Mitchell, L. M., Fu, B., Tyson, J., Shwan, N. A. A., Yang, F., Thomas, M. G., & Armour, J. A. L. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv098 · Cited by 128
Metadata
- Authors
- Michalet, X., Ekong, R., Fougerousse, F., Rousseaux, S., Schurra, C., Hornigold, N., Slegtenhorst, M. V., Wolfe, J., Povey, S., Beckmann, J. S., & Bensimon, A.
- Venue
- Science
- Published
- 1997-09-05
- Volume
- 277
- Issue
- 5331
- Pages
- 1518-1523
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2172164880
- Cited by
- 611
- References
- 0
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Michalet, X., Ekong, R., Fougerousse, F., Rousseaux, S., Schurra, C., Hornigold, N., Slegtenhorst, M. V., Wolfe, J., Povey, S., Beckmann, J. S., & Bensimon, A. (1997). Dynamic Molecular Combing: Stretching the Whole Human Genome for High-Resolution Studies. Science. https://doi.org/10.1126/science.277.5331.1518
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