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Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells
Abstract
The human CD1b protein presents lipid antigens to T cells, but the molecular mechanism is unknown. Identification of mycobacterial glucose monomycolate (GMM) as a CD1b-presented glycolipid allowed determination of the structural requirements for its recognition by T cells. Presentation of GMM to CD1b-restricted T cells was not affected by substantial variations in its lipid tails, but was extremely sensitive to chemical alterations in its carbohydrate or other polar substituents. These findings support the view that the recently demonstrated hydrophobic CD1 groove binds the acyl chains of lipid antigens relatively nonspecifically, thereby positioning the hydrophilic components for highly specific interactions with T cell antigen receptors.
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Citations
Cited by
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Donia, M. S., & Fischbach, M. A. (2015) · Science · doi:10.1126/science.1254766 · Cited by 760
Mycolic Acids: Structures, Biosynthesis, and Beyond
Marrakchi, H., Lanéelle, M.-A., & Daffé, M. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.11.011 · Cited by 623
Burdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., & Kronenberg, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3271 · Cited by 334
Burdin, N., Brossay, L., & Kronenberg, M. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06<2014::aid-immu2014>3.0.co;2-g · Cited by 301
T Cell Activation by Lipopeptide Antigens
Moody, D. B., Young, D. C., Cheng, T.-Y., Rosat, J.-P., Roura-mir, C., O'Connor, P. B., Zajonc, D. M., Walz, A., Miller, M. J., Levery, S. B., et al. (2004) · Science · doi:10.1126/science.1089353 · Cited by 265
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Metadata
- Authors
- Moody, D. B., Reinhold, B. B., Guy, M. R., Beckman, E. M., Frederique, D. E., Furlong, S. T., Ye, S., Reinhold, V. N., Sieling, P. A., Modlin, R. L., Besra, G. S., & Porcelli, S. A.
- Venue
- Science
- Published
- 1997-10-10
- Volume
- 278
- Issue
- 5336
- Pages
- 283-286
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2121968955
- Cited by
- 441
- References
- 0
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moody, D. B., Reinhold, B. B., Guy, M. R., Beckman, E. M., Frederique, D. E., Furlong, S. T., Ye, S., Reinhold, V. N., Sieling, P. A., Modlin, R. L., Besra, G. S., & Porcelli, S. A. (1997). Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells. Science. https://doi.org/10.1126/science.278.5336.283
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
