Small molecules from the human microbiota

Donia, Mohamed S.; Fischbach, Michael A.

doi:10.1126/science.1254766

Cited by 760Microbial Natural Products and BiosynthesisGut microbiota and healthMetabolomics and Mass Spectrometry Studies

Small molecules from the human microbiota

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Donia, Mohamed S., Fischbach, Michael A.·2015·Science

DOI 10.1126/science.1254766PMC PMC4641445

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Abstract

Developments in the use of genomics to guide natural product discovery and a recent emphasis on understanding the molecular mechanisms of microbiota-host interactions have converged on the discovery of small molecules from the human microbiome. Here, we review what is known about small molecules produced by the human microbiota. Numerous molecules representing each of the major metabolite classes have been found that have a variety of biological activities, including immune modulation and antibiosis. We discuss technologies that will affect how microbiota-derived molecules are discovered in the future and consider the challenges inherent in finding specific molecules that are critical for driving microbe-host and microbe-microbe interactions and understanding their biological relevance.

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The gut microbiota produces and releases an enormous array of compounds that may act upon host tissues modulating appetite, gut motility, energy uptake and storage, and energy expenditure.
“the gut microbiota produces and releases an enormous array of compounds which may act upon host tissues modulating appetite, gut motility, energy uptake and storage, and energy expenditure [146, 147].”
From The athletic gut microbiota (2020) · cites this paper as [147]
The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.
“The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.59, 60, 61, 62, 63,64”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [63]

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Gut microbiota in human metabolic health and disease
Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724 · see citing works
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257 · see citing works
Homeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261 · see citing works
Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
The effects of vegetarian and vegan diets on gut microbiota
Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N. D., & Kahleova, H. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00047 · Cited by 713 · see citing works
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor
Scott, S. A., Fu, J., & Chang, P. V. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000047117 · Cited by 696 · see citing works
Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling
Zheng, H., Powell, J. E., Steele, M. I., Dietrich, C., & Moran, N. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701819114 · Cited by 664 · see citing works
Effects of antibiotics on gut microbiota
Lange, K., Buerger, M., Stallmach, A., & Bruns, T. (2016) · Digestive Diseases · doi:10.1159/000443360 · Cited by 607 · see citing works
A metabolic pathway for bile acid dehydroxylation by the gut microbiome
Funabashi, M., Grove, T. L., Wang, M., Varma, Y., McFadden, M. E., Brown, L. C., Guo, C., Higginbottom, S., Almo, S. C., & Fischbach, M. A. (2020) · Nature · doi:10.1038/s41586-020-2396-4 · Cited by 590 · see citing works
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Normalization of host intestinal mucus layers requires long-term microbial colonization
Johansson, M. E. V., Jakobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodríguez-Piñeiro, A. M., Arike, L., Wising, C., Svensson, F., Bäckhed, F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.10.007 · Cited by 549 · see citing works
Exercise and the gut microbiome: A review of the evidence, potential mechanisms, and implications for human health
Mailing, L. J., Allen, J. M., Buford, T. W., Fields, C. J., & Woods, J. A. (2019) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000183 · Cited by 521 · see citing works
The ancestral and industrialized gut microbiota and implications for human health
Sonnenburg, E. D., & Sonnenburg, J. L. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0191-8 · Cited by 489 · see citing works
Fight them or feed them: How the intestinal mucus layer manages the gut microbiota
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Authors: Donia, M. S., & Fischbach, M. A.
Affiliations: Princeton University (US)
QB3 (US)
Corresponding author: Donia, Mohamed S.
Fischbach, Michael A.
ORCID: Donia, Mohamed S.
Fischbach, Michael A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-07-24
Volume: 349
Issue: 6246
Pages: 1254766-1254766
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1254766
PMC: PMC4641445
OpenAlex: W1715339469
Cited by: 760
References: 154
Citations by year: 2026: 47 · 2025: 62 · 2024: 70 · 2023: 66 · 2022: 90 · 2021: 84 · 2020: 85 · 2019: 68 · 2018: 65 · 2017: 55 · 2016: 52 · 2015: 15
FWCI: 7.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (OD007290, AI101018, GM081879, DK101674)
David and Lucile Packard Foundation
Defense Advanced Research Projects Agency (HR0011-12-C-0067)
Burroughs Wellcome Foundation
W.M. Keck Foundation
Princeton University
Program for Breakthrough Biomedical Research
Topics: Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords: human microbiota, natural product discovery, microbiota-host interactions, microbial metabolites, immunomodulation, antibiosis, microbial interactions
MeSH terms: Antibiosis, Bacteriocins, Biological Products, Enterotoxins, Glycolipids, Humans, Oligosaccharides, Peptides, Protein Processing, Post-Translational, Ribosomes, Terpenes, Immunomodulation, Microbiota

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