The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis
Abstract
Proteolysis mediated by the anaphase-promoting complex (APC) triggers chromosome segregation and exit from mitosis, yet its regulation is poorly understood. The conserved Cdc20 and Cdh1 proteins were identified as limiting, substrate-specific activators of APC-dependent proteolysis. CDC20 was required for the degradation of the APC substrate Pds1 but not for that of other APC substrates, such as Clb2 and Ase1. Conversely, cdh1Δ mutants were impaired in the degradation of Ase1 and Clb2 but not in that of Pds1. Overexpression of either CDC20 or CDH1 was sufficient to induce APC-dependent proteolysis of the appropriate target in stages of the cell cycle in which substrates are normally stable.
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Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
How Proteolysis Drives the Cell Cycle
King, R. W., Deshaies, R. J., Peters, J.-M., & Kirschner, M. W. (1996) · Science · doi:10.1126/science.274.5293.1652 · Cited by 1,273
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Peters, J.-M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1988 · Cited by 1,315
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844
Integrative Analysis of Cell Cycle Control in Budding Yeast
Chen, K. C., Calzone, L., Csikasz-Nagy, A., Cross, F. R., Novak, B., & Tyson, J. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0794 · Cited by 632
Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice
Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.019 · Cited by 612
Fang, G., Yu, H., & Kirschner, M. W. (1998) · Genes & Development · doi:10.1101/gad.12.12.1871 · Cited by 594
Metadata
- Authors
- Visintin, R., Prinz, S., & Amon, A.
- Venue
- Science
- Published
- 1997-10-17
- Volume
- 278
- Issue
- 5337
- Pages
- 460-463
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007853809
- Cited by
- 811
- References
- 2
- FWCI
- 19.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Visintin, R., Prinz, S., & Amon, A. (1997). CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis. Science. https://doi.org/10.1126/science.278.5337.460
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
