The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway
Abstract
A mechanism by which members of the ciliary neurotrophic factor (CNTF)–leukemia inhibitory factor cytokine family regulate gliogenesis in the developing mammalian central nervous system was characterized. Activation of the CNTF receptor promoted differentiation of cerebral cortical precursor cells into astrocytes and inhibited differentiation of cortical precursors along a neuronal lineage. Although CNTF stimulated both the Janus kinase–signal transducer and activator of transcription (JAK-STAT) and Ras–mitogen-activated protein kinase signaling pathways in cortical precursor cells, the JAK-STAT signaling pathway selectively enhanced differentiation of these precursors along a glial lineage. These findings suggest that cytokine activation of the JAK-STAT signaling pathway may be a mechanism by which cell fate is controlled during mammalian development.
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Cites
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Self-citationJaks and Stats in signaling by the cytokine receptor superfamily
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Self-citationLIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor
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Carro, M. S., Lim, W. K., Alvarez, M. J., Bollo, R. J., Zhao, X., Snyder, E. Y., Sulman, E. P., Anne, S. L., Doetsch, F., Colman, H., et al. (2010) · Nature · doi:10.1038/nature08712 · Cited by 1,259
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STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
Herrmann, J. E., Imura, T., Song, B., Qi, J., Ao, Y., Nguyen, T. K., Korsak, R. A., Takeda, K., Akira, S., & Sofroniew, M. V. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1709-08.2008 · Cited by 958
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Metadata
- Authors
- Bonni, A., Sun, Y., Nadal-Vicens, M., Bhatt, A., Frank, D. A., Rozovsky, I., Stahl, N., Yancopoulos, G. D., & Greenberg, M. E.
- Venue
- Science
- Published
- 1997-10-17
- Volume
- 278
- Issue
- 5337
- Pages
- 477-483
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091898207
- Cited by
- 1,013
- References
- 28
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bonni, A., Sun, Y., Nadal-Vicens, M., Bhatt, A., Frank, D. A., Rozovsky, I., Stahl, N., Yancopoulos, G. D., & Greenberg, M. E. (1997). Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway. Science. https://doi.org/10.1126/science.278.5337.477
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
