The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis
Abstract
Induction of apoptosis by oncogenes like c- myc may be important in restraining the emergence of neoplasia. However, the mechanism by which c- myc induces apoptosis is unknown. CD95 (also termed Fas or APO-1) is a cell surface transmembrane receptor of the tumor necrosis factor receptor family that activates an intrinsic apoptotic suicide program in cells upon binding either its ligand CD95L or antibody. c- myc –induced apoptosis was shown to require interaction on the cell surface between CD95 and its ligand. c-Myc acts downstream of the CD95 receptor by sensitizing cells to the CD95 death signal. Moreover, IGF-I signaling and Bcl-2 suppress c- myc –induced apoptosis by also acting downstream of CD95. These findings link two apoptotic pathways previously thought to be independent and establish the dependency of Myc on CD95 signaling for its killing activity.
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Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979
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Cited by
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Proliferation, cell cycle and apoptosis in cancer
Evan, G. I., & Vousden, K. H. (2001) · Nature · doi:10.1038/35077213 · Cited by 2,724
Self-citationThe Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333
Green, D. R., & Evan, G. I. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00024-7 · Cited by 1,254
Self-citationKasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., & Green, D. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80054-4 · Cited by 721
Metadata
- Authors
- Hueber, A.-O., Zörnig, M., Lyon, D., Suda, T., Nagata, S., & Evan, G. I.
- Venue
- Science
- Published
- 1997-11-14
- Volume
- 278
- Issue
- 5341
- Pages
- 1305-1309
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2093515639
- Cited by
- 370
- References
- 1
- FWCI
- 18.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hueber, A.-O., Zörnig, M., Lyon, D., Suda, T., Nagata, S., & Evan, G. I. (1997). Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis. Science. https://doi.org/10.1126/science.278.5341.1305
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
