The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling
Abstract
Tiam1 encodes an exchange factor for the Rho-like guanosine triphosphatase Rac. Both Tiam1 and activated RacV12 promote invasiveness of T lymphoma cells. In epithelial Madin–Darby canine kidney (MDCK) cells, Tiam1 localized to adherens junctions. Ectopic expression of Tiam1 or RacV12 inhibited hepatocyte growth factor–induced scattering by increasing E-cadherin–mediated cell-cell adhesion accompanied by actin polymerization at cell-cell contacts. In Ras-transformed MDCK cells, expression of Tiam1 or RacV12 restored E-cadherin–mediated adhesion, resulting in phenotypic reversion and loss of invasiveness. These data suggest an invasion-suppressor role for Tiam1 and Rac in epithelial cells.
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Cites
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CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION
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An essential role for Rac in Ras transformation
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Cited by
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180
Vestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806
Sander, E. E., van Delft, S., ten Klooster, J. P., Reid, T., van der Kammen, R. A., Michiels, F., & Collard, J. G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1385 · Cited by 659
Self-citationThe ‘invisible hand’: Regulation of RHO GTPases by RHOGDIs
Garcia-Mata, R., Boulter, E., & Burridge, K. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3153 · Cited by 560
Metadata
- Authors
- Hordijk, P. L., ten Klooster, J. P., van der Kammen, R. A., Michiels, F., Oomen, L. C. J. M., & Collard, J. G.
- Venue
- Science
- Published
- 1997-11-21
- Volume
- 278
- Issue
- 5342
- Pages
- 1464-1466
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987888289
- Cited by
- 441
- References
- 24
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hordijk, P. L., ten Klooster, J. P., van der Kammen, R. A., Michiels, F., Oomen, L. C. J. M., & Collard, J. G. (1997). Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling. Science. https://doi.org/10.1126/science.278.5342.1464
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
