The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras
Abstract
The ras proto-oncogene is frequently mutated in human tumors and functions to chronically stimulate signal transduction cascades resulting in the synthesis or activation of specific transcription factors, including Ets, c-Myc, c-Jun, and nuclear factor kappa B (NF-κB). These Ras-responsive transcription factors are required for transformation, but the mechanisms by which these proteins facilitate oncogenesis have not been fully established. Oncogenic Ras was shown to initiate a p53-independent apoptotic response that was suppressed through the activation of NF-κB. These results provide an explanation for the requirement of NF-κB for Ras-mediated oncogenesis and provide evidence that Ras-transformed cells are susceptible to apoptosis even if they do not express the p53 tumor-suppressor gene product.
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Cites
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Comprehensive genomic characterization of head and neck squamous cell carcinomas
The Cancer Genome Atlas Network (2015) · Nature · doi:10.1038/nature14129 · Cited by 3,877
Epidermal growth factor receptor mutations in lung cancer
Sharma, S. V., Bell, D. W., Settleman, J., & Haber, D. A. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2088 · Cited by 3,170
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
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Ras oncogenes: split personalities
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NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
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Self-citation
Metadata
- Authors
- Mayo, M. W., Wang, C.-Y., Cogswell, P. C., Rogers-Graham, K. S., Lowe, S. W., Der, C. J., & Baldwin, A. S.
- Venue
- Science
- Published
- 1997-12-05
- Volume
- 278
- Issue
- 5344
- Pages
- 1812-1815
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2172010722
- Cited by
- 533
- References
- 49
- FWCI
- 20.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mayo, M. W., Wang, C.-Y., Cogswell, P. C., Rogers-Graham, K. S., Lowe, S. W., Der, C. J., & Baldwin, A. S. (1997). Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras. Science. https://doi.org/10.1126/science.278.5344.1812
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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