The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex
Abstract
An oligomer of the Sec61 trimeric complex is thought to form the protein-conducting channel for protein transport across the endoplasmic reticulum. A purified yeast Sec61 complex bound to monomeric yeast ribosomes as an oligomer in a saturable fashion. Cryo–electron microscopy of the ribosome-Sec61 complex and a three-dimensional reconstruction showed that the Sec61 oligomer is attached to the large ribosomal subunit by a single connection. Moreover, a funnel-shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both structures function together in the translocation of proteins across the endoplasmic reticulum membrane.
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Cites
Blobel, G., & Dobberstein, B. (1975) · The Journal of cell biology · doi:10.1083/jcb.67.3.835 · Cited by 3,002
Self-citationCryo-electron microscopy of vitrified specimens
Dubochet, J., Adrian, M., Chang, J.-J., Homo, J.-C., Lepault, J., McDowall, A. W., & Schultz, P. (1988) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500004297 · Cited by 2,389
Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy
Böttcher, B., Wynne, S. A., & Crowther, R. A. (1997) · Nature · doi:10.1038/386088a0 · Cited by 791
A protein-conducting channel in the endoplasmic reticulum
Simon, S. M., & Blobel, G. (1991) · Cell · doi:10.1016/0092-8674(91)90455-8 · Cited by 619
Self-citationGörlich, D., Prehn, S., Hartmann, E., Kalies, K.-U., & Rapoport, T. A. (1992) · Cell · doi:10.1016/0092-8674(92)90517-g · Cited by 454
Deshaies, R. J., & Schekman, R. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.2.633 · Cited by 415
Penczek, P. A., Grassucci, R. A., & Frank, J. (1994) · Ultramicroscopy · doi:10.1016/0304-3991(94)90038-8 · Cited by 414
Self-citationA model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome
Frank, J., Zhu, J., Penczek, P., Li, Y., Srivastava, S., Verschoor, A., Radermacher, M., Grassucci, R., Lata, R. K., & Agrawal, R. K. (1995) · Nature · doi:10.1038/376441a0 · Cited by 394
Self-citationPanzner, S., Dreier, L., Hartmann, E., Kostka, S., & Rapoport, T. A. (1995) · Cell · doi:10.1016/0092-8674(95)90077-2 · Cited by 393
Stirling, C. J., Rothblatt, J., Hosobuchi, M., Deshaies, R., & Schekman, R. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.2.129 · Cited by 349
Cited by
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
Ban, N., Nissen, P., Hansen, J., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.905 · Cited by 3,327
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
Nissen, P., Hansen, J., Ban, N., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.920 · Cited by 2,269
X-ray structure of a protein-conducting channel
Berg, B. V. D., Clemons, W. M., Collinson, I., Modis, Y., Hartmann, E., Harrison, S. C., & Rapoport, T. A. (2004) · Nature · doi:10.1038/nature02218 · Cited by 1,250
Fourier shell correlation threshold criteria
van Heel, M., & Schatz, M. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.05.009 · Cited by 927
Measuring image resolution in optical nanoscopy
Nieuwenhuizen, R. P. J., Lidke, K. A., Bates, M., Puig, D. L., Grünwald, D., Stallinga, S., & Rieger, B. (2013) · Nature Methods · doi:10.1038/nmeth.2448 · Cited by 800
Metadata
- Authors
- Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., & Frank, J.
- Venue
- Science
- Published
- 1997-12-19
- Volume
- 278
- Issue
- 5346
- Pages
- 2123-2126
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071748696
- Cited by
- 347
- References
- 22
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., & Frank, J. (1997). Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex. Science. https://doi.org/10.1126/science.278.5346.2123
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
