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Mismatch Repair Co-opted by Hypermutation
Abstract
Mice homozygous for a disrupted allele of the mismatch repair gene Pms2 have a mutator phenotype. When this allele is crossed into quasi-monoclonal (QM) mice, which have a very limited B cell repertoire, homozygotes have fewer somatic mutations at the immunoglobulin heavy chain and λ chain loci than do heterozygotes or wild-type QM mice. That is, mismatch repair seems to contribute to somatic hypermutation rather than stifling it. It is suggested that at immunoglobulin loci in hypermutable B cells, mismatched base pairs are “corrected” according to the newly synthesized DNA strand, thereby fixing incipient mutations instead of eliminating them.
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Cited by
Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,647
The multifaceted mismatch-repair system
Jiricny, J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1907 · Cited by 1,370
Jeffery, C. J. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01335-8 · Cited by 1,016
DNA Mismatch Repair: Functions and Mechanisms
Iyer, R. R., Pluciennik, A., Burdett, V., & Modrich, P. L. (2006) · Chemical Reviews · doi:10.1021/cr0404794 · Cited by 905
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
Harfe, B. D., & Jinks-Robertson, S. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.359 · Cited by 608
Metadata
- Authors
- Cascalho, M., Wong, J., Steinberg, C., & Wabl, M.
- Venue
- Science
- Published
- 1998-02-20
- Volume
- 279
- Issue
- 5354
- Pages
- 1207-1210
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985067006
- Cited by
- 159
- References
- 0
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
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