The DOI matches its Crossref record.
Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C
Abstract
Receptor tyrosine kinase–mediated activation of the Raf-1 protein kinase is coupled to the small guanosine triphosphate (GTP)–binding protein Ras. By contrast, protein kinase C (PKC)–mediated activation of Raf-1 is thought to be Ras independent. Nevertheless, stimulation of PKC in COS cells led to activation of Ras and formation of Ras–Raf-1 complexes containing active Raf-1. Raf-1 mutations that prevent its association with Ras blocked activation of Raf-1 by PKC. However, the activation of Raf-1 by PKC was not blocked by dominant negative Ras, indicating that PKC activates Ras by a mechanism distinct from that initiated by activation of receptor tyrosine kinases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
MAP kinase signalling pathways in cancer
Dhillon, A. S., Hagan, S., Rath, O., & Kolch, W. (2007) · Oncogene · doi:10.1038/sj.onc.1210421 · Cited by 2,995
Epidermal growth factor receptor: Mechanisms of activation and signalling
Jorissen, R. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00098-8 · Cited by 1,565
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284
RAS Interaction with PI3K: More Than Just Another Effector Pathway
Castellano, E., & Downward, J. (2011) · Genes & Cancer · doi:10.1177/1947601911408079 · Cited by 762
The exocyst is a Ral effector complex
Moskalenko, S., Henry, D. O., Rosse, C., Mirey, G., Camonis, J. H., & White, M. A. (2002) · Nature Cell Biology · doi:10.1038/ncb728 · Cited by 423
Biological and Pharmacological Aspects of the NK1-Receptor
Garcia-Recio, S., & Gascón, P. (2015) · BioMed Research International · doi:10.1155/2015/495704 · Cited by 226
Activation of c-Raf Kinase by Ultraviolet Light
Hoyos, B., Imam, A., Korichneva, I., Levi, E., Chua, R., & Hammerling, U. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110750200 · Cited by 55
Guo, B., & Rothstein, T. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5375 · Cited by 31
Metadata
- Authors
- Marais, R., Light, Y., Mason, C., Paterson, H., Olson, M. F., & Marshall, C. J.
- Venue
- Science
- Published
- 1998-04-03
- Volume
- 280
- Issue
- 5360
- Pages
- 109-112
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001895687
- Cited by
- 441
- References
- 0
- FWCI
- 19.81
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
