The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus
Abstract
Degradation of invariant chain (Ii) is a critical step in major histocompatibility complex class II–restricted antigen presentation. Cathepsin L was found to be necessary for Ii degradation in cortical thymic epithelial cells (cTECs), but not in bone marrow (BM)–derived antigen-presenting cells (APCs). Consequently, positive selection of CD4 + T cells was reduced. Because different cysteine proteinases are responsible for specific Ii degradation steps in cTECs and BM-derived APCs, the proteolytic environment in cells mediating positive and negative selection may be distinct. The identification of a protease involved in class II presentation in a tissue-specific manner suggests a potential means of manipulating CD4 + T cell responsiveness in vivo.
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Cites
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Structure of Peptides Associated with Class I and Class II MHC Molecules
Engelhard, V. H. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.181 · Cited by 395
Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway
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Self-citationWolf, P. R., & Ploegh, H. L. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.001411 · Cited by 278
Self-citationNegative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Denzin, L. K., Sant'Angelo, D. B., Hammond, C., Surman, M. J., & Cresswell, P. (1997) · Science · doi:10.1126/science.278.5335.106 · Cited by 234
Villadangos, J. A., Riese, R. J., Peters, C., Chapman, H. A., & Ploegh, H. L. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.4.549 · Cited by 188
Self-citationIa invariant chain detected on lymphocyte surfaces by monoclonal antibody
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Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells
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Positive Selection of Thymocytes
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Cited by
Cysteine cathepsins: From structure, function and regulation to new frontiers
Turk, V., Stoka, V., Vasiljeva, O., Renko, M., Sun, T., Turk, B., & Turk, D. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.10.002 · Cited by 1,377
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
Derbinski, J., Schulte, A., Kyewski, B., & Klein, L. (2001) · Nature Immunology · doi:10.1038/ni723 · Cited by 1,077
Klein, J., & Sato, A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009073431006 · Cited by 906
NEW EMBO MEMBERS' REVIEW: Lysosomal cysteine proteases: facts and opportunities
Turk, V. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4629 · Cited by 756
Protease degradomics: A new challenge for proteomics
López-Otín, C., & Overall, C. M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm858 · Cited by 664
Metadata
- Authors
- Nakagawa, T., Roth, W., Wong, P., Nelson, A., Farr, A., Deussing, J., Villadangos, J. A., Ploegh, H., Peters, C., & Rudensky, A. Y.
- Venue
- Science
- Published
- 1998-04-17
- Volume
- 280
- Issue
- 5362
- Pages
- 450-453
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055480930
- Cited by
- 674
- References
- 12
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus. https://app.cochat.ai/papers/10.1126/science.280.5362.450
- The paper
- Nakagawa, T., Roth, W., Wong, P., Nelson, A., Farr, A., Deussing, J., Villadangos, J. A., Ploegh, H., Peters, C., & Rudensky, A. Y. (1998). Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus. Science. https://doi.org/10.1126/science.280.5362.450
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
