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Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Abstract
HLA-DM is a major histocompatibility complex (MHC) class II–like molecule that facilitates antigen processing by catalyzing the exchange of invariant chain–derived peptides (CLIP) from class II molecules for antigenic peptides. HLA-DO is a second class II–like molecule that physically associates with HLA-DM in B cells. HLA-DO was shown to block HLA-DM function. Purified HLA-DM-DO complexes could not promote peptide exchange in vitro. Expression of HLA-DO in a class II + and DM + , DO − human T cell line caused the accumulation of class II–CLIP complexes, indicating that HLA-DO blocked DM function in vivo and suggesting that HLA-DO is an important modulator of class II–restricted antigen processing.
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Hammond, C., & Helenius, A. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.1.41 · Cited by 443
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Metadata
- Authors
- Denzin, L. K., Sant'Angelo, D. B., Hammond, C., Surman, M. J., & Cresswell, P.
- Venue
- Science
- Published
- 1997-10-03
- Volume
- 278
- Issue
- 5335
- Pages
- 106-109
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046563727
- Cited by
- 234
- References
- 1
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Denzin, L. K., Sant'Angelo, D. B., Hammond, C., Surman, M. J., & Cresswell, P. (1997). Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing. Science. https://doi.org/10.1126/science.278.5335.106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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