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Formation of a Preinitiation Complex by S-phase Cyclin CDK-Dependent Loading of Cdc45p onto Chromatin
Abstract
Cdc45p, a protein essential for initiation of DNA replication, associates with chromatin after “start” in late G 1 and during the S phase of the cell cycle. Binding of Cdc45p to chromatin depends on Clb-Cdc28 kinase activity as well as functional Cdc6p and Mcm2p, which suggests that Cdc45p associates with the prereplication complex after activation of S-phase cyclin-dependent kinases (CDKs). As indicated by the timing and the CDK dependence, binding of Cdc45p to chromatin is crucial for commitment to initiation of DNA replication. During S phase, Cdc45p physically interacts with minichromosome maintenance (MCM) proteins on chromatin; however, dissociation of Cdc45p from chromatin is slower than that of MCMs, which indicates that the proteins are released by different mechanisms.
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Cited by
DNA Replication in Eukaryotic Cells
Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,060
Self-Assembling Protein Microarrays
Ramachandran, N., Hainsworth, E., Bhullar, B., Eisenstein, S., Rosen, B., Lau, A. Y., Walter, J. C., & LaBaer, J. (2004) · Science · doi:10.1126/science.1097639 · Cited by 548
Evrin, C., Clarke, P., Zech, J., Lurz, R., Sun, J., Uhle, S., Li, H., Stillman, B., & Speck, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911500106 · Cited by 536
Self-citationInitiation of Eukaryotic DNA Replication
Walter, J., & Newport, J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80241-5 · Cited by 425
Regulation of Chromosome Replication
Kelly, T. J., & Brown, G. W. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.829 · Cited by 401
Metadata
- Authors
- Zou, L., & Stillman, B.
- Venue
- Science
- Published
- 1998-04-24
- Volume
- 280
- Issue
- 5363
- Pages
- 593-596
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985710832
- Cited by
- 326
- References
- 0
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zou, L., & Stillman, B. (1998). Formation of a Preinitiation Complex by S-phase Cyclin CDK-Dependent Loading of Cdc45p onto Chromatin. Science. https://doi.org/10.1126/science.280.5363.593
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