The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System
Abstract
Ataxia telangiectasia (AT) is characterized by progressive neurodegeneration that results from mutation of the ATM gene. However, neither the normal function of ATM in the nervous system nor the biological basis of the degeneration in AT is known. Resistance to apoptosis in the developing central nervous system (CNS) of Atm −/− mice was observed after ionizing radiation. This lack of death occurred in diverse regions of the CNS, including the cerebellum, which is markedly affected in AT. In wild-type, but not Atm −/− mice, up-regulation of p53 coincided with cell death, suggesting that Atm-dependent apoptosis in the CNS is mediated by p53. Further, p53 null mice showed a similar lack of radiation-induced cell death in the developing nervous system. Atm may function at a developmental survival checkpoint that serves to eliminate neurons with excessive DNA damage.
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Cites
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p53 is required for radiation-induced apoptosis in mouse thymocytes
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A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
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Cited by
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
Flores, E. R., Tsai, K. Y., Crowley, D., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 802
Fei, P., & El-Deiry, W. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206677 · Cited by 498
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
Cosentino, C., Grieco, D., & Costanzo, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.330 · Cited by 435
Metadata
- Authors
- Herzog, K.-H., Chong, M. J., Kapsetaki, M., Morgan, J. I., & McKinnon, P. J.
- Venue
- Science
- Published
- 1998-05-15
- Volume
- 280
- Issue
- 5366
- Pages
- 1089-1091
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088013332
- Cited by
- 422
- References
- 18
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Herzog, K.-H., Chong, M. J., Kapsetaki, M., Morgan, J. I., & McKinnon, P. J. (1998). Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System. Science. https://doi.org/10.1126/science.280.5366.1089
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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