The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis
Abstract
Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi , the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401 . The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function–associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.
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Citations
Cites
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Self-citationThe Clinical Evolution of Lyme Arthritis
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Self-citationMHC Class-II Molecules and Autoimmunity
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Promiscuous and allele-specific anchors in HLA-DR-binding peptides
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Association of Chronic Lyme Arthritis with HLA-DR4 and HLA-DR2 Alleles
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Self-citationPeptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association.
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Self-citation
Cited by
Wormser, G. P., Dattwyler, R. J., Shapiro, E. D., Halperin, J. J., Steere, A. C., Klempner, M. S., Krause, P. J., Bakken, J. S., Strle, F., Stanek, G., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/508667 · Cited by 2,087
Self-citationSteere, A. C., Coburn, J., & Glickstein, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421681 · Cited by 788
Self-citationSteere, A. C., Sikand, V. K., Meurice, F., Parenti, D. L., Fikrig, E., Schoen, R. T., Nowakowski, J., Schmid, C. H., Laukamp, S., Buscarino, C., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390401 · Cited by 746
Self-citationAguero-Rosenfeld, M. E., Wang, G., Schwartz, I., & Wormser, G. P. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.3.484-509.2005 · Cited by 744
Autoimmune disease: why and where it occurs
Marrack, P., Kappler, J., & Kotzin, B. L. (2001) · Nature Medicine · doi:10.1038/90935 · Cited by 609
Metadata
- Authors
- Gross, D. M., Forsthuber, T., Tary-Lehmann, M., Etling, C., Ito, K., Nagy, Z. A., Field, J. A., Steere, A. C., & Huber, B. T.
- Venue
- Science
- Published
- 1998-07-31
- Volume
- 281
- Issue
- 5377
- Pages
- 703-706
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071985786
- Cited by
- 517
- References
- 19
- FWCI
- 38.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis. https://app.cochat.ai/papers/10.1126/science.281.5377.703
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- Gross, D. M., Forsthuber, T., Tary-Lehmann, M., Etling, C., Ito, K., Nagy, Z. A., Field, J. A., Steere, A. C., & Huber, B. T. (1998). Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis. Science. https://doi.org/10.1126/science.281.5377.703
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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