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Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis
Abstract
Control of the activation of apoptosis is important both in development and in protection against cancer. In the classic genetic model Caenorhabditis elegans , the pro-apoptotic protein CED-4 activates the CED-3 caspase and is inhibited by the Bcl-2–like protein CED-9. Both processes are mediated by protein-protein interaction. Facilitating the proximity of CED-3 zymogen molecules was found to induce caspase activation and cell death. CED-4 protein oligomerized in cells and in vitro. This oligomerization induced CED-3 proximity and competed with CED-4:CED-9 interaction. Mutations that abolished CED-4 oligomerization inactivated its ability to activate CED-3. Thus, the mechanism of control is that CED-3 in CED-3:CED-4 complexes is activated by CED-4 oligomerization, which is inhibited by binding of CED-9 to CED-4.
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Cited by
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
Chai, J., Du, C., Wu, J.-W., Kyin, S., Wang, X., & Shi, Y. (2000) · Nature · doi:10.1038/35022514 · Cited by 864
Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB
Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14560 · Cited by 742
Caspase-9 Can Be Activated without Proteolytic Processing
Stennicke, H. R., Deveraux, Q. L., Humke, E. W., Reed, J. C., Dixit, V. M., & Salvesen, G. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8359 · Cited by 497
Metadata
- Authors
- Yang, X., Chang, H. Y., & Baltimore, D.
- Venue
- Science
- Published
- 1998-08-28
- Volume
- 281
- Issue
- 5381
- Pages
- 1355-1357
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2140951631
- Cited by
- 267
- References
- 0
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, X., Chang, H. Y., & Baltimore, D. (1998). Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis. Science. https://doi.org/10.1126/science.281.5381.1355
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