The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition
Abstract
Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin light chain–2, or fetal β-tropomyosin in the heart. Cyclosporin had a similar effect in a rat model of pressure-overload hypertrophy. These results suggest that calcineurin inhibitors merit investigation as potential therapeutics for certain forms of human heart disease.
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Cites
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Cited by
Calcineurin: Form and Function
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Self-citationGeneric Signals and Specific Outcomes
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Metadata
- Authors
- Sussman, M. A., Lim, H. W., Gude, N., Taigen, T., Olson, E. N., Robbins, J., Colbert, M. C., Gualberto, A., Wieczorek, D. F., & Molkentin, J. D.
- Venue
- Science
- Published
- 1998-09-11
- Volume
- 281
- Issue
- 5383
- Pages
- 1690-1693
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010791119
- Cited by
- 461
- References
- 18
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sussman, M. A., Lim, H. W., Gude, N., Taigen, T., Olson, E. N., Robbins, J., Colbert, M. C., Gualberto, A., Wieczorek, D. F., & Molkentin, J. D. (1998). Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition. Science. https://doi.org/10.1126/science.281.5383.1690
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
