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Cited by 7,278

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection

Chan, Warren C. W., Nie, Shuming·1998·Science

Abstract

Highly luminescent semiconductor quantum dots (zinc sulfide–capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection. In comparison with organic dyes such as rhodamine, this class of luminescent labels is 20 times as bright, 100 times as stable against photobleaching, and one-third as wide in spectral linewidth. These nanometer-sized conjugates are water-soluble and biocompatible. Quantum dots that were labeled with the protein transferrin underwent receptor-mediated endocytosis in cultured HeLa cells, and those dots that were labeled with immunomolecules recognized specific antibodies or antigens.

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Metadata

Authors
Chan, W. C. W., & Nie, S.
Venue
Science
Published
1998-09-25
Volume
281
Issue
5385
Pages
2016-2018
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2094437628
Cited by
7,278
References
2
FWCI
51.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection. https://app.cochat.ai/papers/10.1126/science.281.5385.2016
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Chan, W. C. W., & Nie, S. (1998). Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection. Science. https://doi.org/10.1126/science.281.5385.2016

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.