The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point
Abstract
Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of access, drug intake gradually escalated over days. After escalation, drug consumption was characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point. After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction.
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Citations
Cites
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Self-citationGawin, F. H., & Ellinwood, E. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805053181806 · Cited by 965
Cited by
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
Self-citationDrug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Self-citationDysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507
Metadata
- Authors
- Ahmed, S. H., & Koob, G. F.
- Venue
- Science
- Published
- 1998-10-09
- Volume
- 282
- Issue
- 5387
- Pages
- 298-300
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2087657646
- Cited by
- 1,154
- References
- 2
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ahmed, S. H., & Koob, G. F. (1998). Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point. Science. https://doi.org/10.1126/science.282.5387.298
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
