The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine
Abstract
CD8 + cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8 + T cell responses. Malaria-naı̈ve volunteers who were vaccinated with plasmid DNA encoding a malaria protein developed antigen-specific, genetically restricted, CD8 + T cell–dependent CTLs. Responses were directed against all 10 peptides tested and were restricted by six human lymphocyte antigen (HLA) class I alleles. This first demonstration in healthy naı̈ve humans of the induction of CD8 + CTLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology.
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Cites
Direct Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
Cited by
DNA Vaccines: Immunology, Application, and Optimization
Gurunathan, S., Klinman, D. M., & Seder, R. A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.927 · Cited by 1,207
DNA vaccines: ready for prime time?
Kutzler, M. A., & Weiner, D. B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2432 · Cited by 1,077
DNA Vaccines: Progress and Challenges
Donnelly, J. J., Wahren, B., & Liu, M. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.2.633 · Cited by 448
Distribution of DNA Vaccines Determines Their Immunogenicity After Intramuscular Injection in Mice
Dupuis, M., Denis-Mize, K., Woo, C., Goldbeck, C., Selby, M. J., Chen, M., Otten, G. R., Ulmer, J. B., Donnelly, J. J., Ott, G., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2850 · Cited by 327
Current status of malaria and potential for control
Phillips, R. S. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.1.208-226.2001 · Cited by 266
Metadata
- Authors
- Wang, R., Doolan, D. L., Le, T. P., Hedstrom, R. C., Coonan, K. M., Charoenvit, Y., Jones, T. R., Hobart, P., Margalith, M., Ng, J., Weiss, W. R., Sedegah, M., de Taisne, C., A. Norman, J., & Hoffman, S. L.
- Venue
- Science
- Published
- 1998-10-16
- Volume
- 282
- Issue
- 5388
- Pages
- 476-480
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2132042285
- Cited by
- 833
- References
- 1
- FWCI
- 34.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, R., Doolan, D. L., Le, T. P., Hedstrom, R. C., Coonan, K. M., Charoenvit, Y., Jones, T. R., Hobart, P., Margalith, M., Ng, J., Weiss, W. R., Sedegah, M., de Taisne, C., A. Norman, J., & Hoffman, S. L. (1998). Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine. Science. https://doi.org/10.1126/science.282.5388.476
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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