The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah
Abstract
Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah ( mth ) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate–binding protein–coupled seven–transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.
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Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Tatar, M., Khazaeli, A. A., & Curtsinger, J. W. (1997) · Nature · doi:10.1038/36237 · Cited by 332
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Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
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Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
An epigenetic biomarker of aging for lifespan and healthspan
Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., et al. (2018) · Aging · doi:10.18632/aging.101414 · Cited by 3,675
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774
Metadata
- Authors
- Lin, Y.-J., Seroude, L., & Benzer, S.
- Venue
- Science
- Published
- 1998-10-30
- Volume
- 282
- Issue
- 5390
- Pages
- 943-946
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062048451
- Cited by
- 815
- References
- 3
- FWCI
- 18.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lin, Y.-J., Seroude, L., & Benzer, S. (1998). Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah. Science. https://doi.org/10.1126/science.282.5390.943
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
