The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Transformation of Tooth Type Induced by Inhibition of BMP Signaling
Abstract
Mammalian dentitions are highly patterned, with different types of teeth positioned in different regions of the jaws. BMP4 is an early oral epithelial protein signal that directs odontogenic gene expression in mesenchyme cells of the developing mandibular arch. BMP4 was shown to inhibit expression of the homeobox gene Barx-1 and to restrict expression to the proximal, presumptive molar mesenchyme of mouse embryos at embryonic day 10. The inhibition of BMP signaling early in mandible development by the action of exogenous Noggin protein resulted in ectopic Barx-1 expression in the distal, presumptive incisor mesenchyme and a transformation of tooth identity from incisor to molar.
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Cites
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
Zimmerman, L. B., De Jesús-Escobar, J. M., & Harland, R. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80133-6 · Cited by 1,633
Vainio, S. J., Karavanova, I. D., Jowett, A. K., & Thesleff, I. (1993) · Cell · doi:10.1016/0092-8674(93)90678-j · Cited by 924
The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues
Noden, D. M. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90318-4 · Cited by 870
Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny
Köntges, G., & Lumsden, A. (1996) · Development · doi:10.1242/dev.122.10.3229 · Cited by 671
Neubüser, A., Peters, H., Balling, R., & Martin, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80333-5 · Cited by 609
Grigoriou, M., Tucker, A. S., Sharpe, P. T., & Pachnis, V. (1998) · Development · doi:10.1242/dev.125.11.2063 · Cited by 312
Self-citationRole of Dlx-1 and Dlx-2 genes in patterning of the murine dentition
Thomas, B. L., Tucker, A. S., Qiu, M., Ferguson, C. A., Hardcastle, Z., Rubenstein, J. L. R., & Sharpe, P. T. (1997) · Development · doi:10.1242/dev.124.23.4811 · Cited by 270
Self-citationFerguson, C. A., Tucker, A. S., Christensen, L., Lau, A. L., Matzuk, M. M., & Sharpe, P. T. (1998) · Genes & Development · doi:10.1101/gad.12.16.2636 · Cited by 220
Self-citationEarly expression ofAMH in chicken embryonic gonads precedes testicularSOX9 expression
Oréal, E., Pieau, C., Mattéi, M., Josso, N., Picard, J., Carre, D. S., & Magre, S. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199808)212:4<533::aid-aja6>3.0.co;2-i · Cited by 196
The Hox11 gene is essential for cell survival during spleen development
Dear, T. N., Colledge, W. H., Carlton, M. B. L., Lavenir, I., Larson, T., Smith, A. J. H., Warren, A. J., Evans, M. J., Sofroniew, M. V., & Rabbitts, T. H. (1995) · Development · doi:10.1242/dev.121.9.2909 · Cited by 168
Cited by
Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
Chang, H., Brown, C. W., & Matzuk, M. M. (2002) · Endocrine Reviews · doi:10.1210/er.2002-0003 · Cited by 787
Dental Functional Morphology: How Teeth Work
Lucas, P. W. (2004) · doi:10.1017/cbo9780511735011 · Cited by 550
Mechanisms of ectodermal organogenesis.
Pispa, J., & Thesleff, I. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00325-7 · Cited by 499
Specification of Jaw Subdivisions by Dlx Genes
Depew, M. J., Lufkin, T., & Rubenstein, J. L. R. (2002) · Science · doi:10.1126/science.1075703 · Cited by 465
A gene network model accounting for development and evolution of mammalian teeth
Salazar-Ciudad, I., & Jernvall, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132069499 · Cited by 393
Metadata
- Authors
- Tucker, A. S., Matthews, K. L., & Sharpe, P. T.
- Venue
- Science
- Published
- 1998-11-06
- Volume
- 282
- Issue
- 5391
- Pages
- 1136-1138
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980880596
- Cited by
- 447
- References
- 14
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
