The DOI matches its Crossref record; 393 of the 393 references it cites were found in a registry or an index.
Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
Abstract
Members of the TGF-beta superfamily, which includes TGF-betas, growth differentiation factors, bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic factor, are synthesized as prepropeptide precursors and then processed and secreted as homodimers or heterodimers. Most ligands of the family signal through transmembrane serine/threonine kinase receptors and SMAD proteins to regulate cellular functions. Many studies have reported the characterization of knockout and knock-in transgenic mice as well as humans or other mammals with naturally occurring genetic mutations in superfamily members or their regulatory proteins. These investigations have revealed that TGF-beta superfamily ligands, receptors, SMADs, and upstream and downstream regulators function in diverse developmental and physiological pathways. This review attempts to collate and integrate the extensive body of in vivo mammalian studies produced over the last decade.
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Cited by
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947
Carano, R. A. D., & Filvaroff, E. H. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02866-6 · Cited by 746
Development of TGF-β signalling inhibitors for cancer therapy
Yingling, J. M., Blanchard, K. L., & Sawyer, J. S. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1580 · Cited by 549
Transforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
TGF-β superfamily expression and actions in the endometrium and placenta
Jones, R. L., Stoikos, C., Findlay, J. K., & Salamonsen, L. A. (2006) · Reproduction · doi:10.1530/rep.1.01076 · Cited by 408
Metadata
- Authors
- Chang, H., Brown, C. W., & Matzuk, M. M.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2002-12-01
- Volume
- 23
- Issue
- 6
- Pages
- 787-823
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2077243848
- Cited by
- 787
- References
- 393
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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