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Reovirus Therapy of Tumors with Activated Ras Pathway
Abstract
Human reovirus requires an activated Ras signaling pathway for infection of cultured cells. To investigate whether this property can be exploited for cancer therapy, severe combined immune deficient mice bearing tumors established from v- erbB –transformed murine NIH 3T3 cells or human U87 glioblastoma cells were treated with the virus. A single intratumoral injection of virus resulted in regression of tumors in 65 to 80 percent of the mice. Treatment of immune-competent C3H mice bearing tumors established from ras -transformed C3H-10T1/2 cells also resulted in tumor regression, although a series of injections were required. These results suggest that, with further work, reovirus may have applicability in the treatment of cancer.
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Citations
Cited by
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Karnoub, A. E., & Weinberg, R. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2438 · Cited by 1,467
Metabolism, Cell Surface Organization, and Disease
Dennis, J. W., Nabi, I. R., & Demetriou, M. (2009) · Cell · doi:10.1016/j.cell.2009.12.008 · Cited by 450
Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer
Kirn, D. H., & Thorne, S. H. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2545 · Cited by 402
Thomas, S., Izard, J., Walsh, E., Batich, K., Chongsathidkiet, P., Clarke, G., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 367
Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication
Bergmann, M., Garcia-Sastre, A., Carnero, E., Pehamberger, H., Wolff, K., Palese, P., & Muster, T. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.6203-6206.2000 · Cited by 362
Metadata
- Authors
- Coffey, M. C., Strong, J. E., Forsyth, P. A., & Lee, P. W. K.
- Venue
- Science
- Published
- 1998-11-13
- Volume
- 282
- Issue
- 5392
- Pages
- 1332-1334
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090599158
- Cited by
- 750
- References
- 0
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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