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A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene
Abstract
Growth factors and their receptors are involved in the regulation of cell proliferation and also play a key role in oncogenesis. In this study, a novel putative kinase receptor gene, termed eph , has been identified and characterized by molecular cloning. Its primary structure is similar to that of tyrosine kinase receptors thus far cloned and includes a cysteine-rich region in the extracellular domain. However, other features of the sequence distinguish the eph gene product from known receptors with tyrosine kinase activity. Thus the eph protein may define a new class of these molecules. The eph gene is overexpressed in several human carcinomas, suggesting that this gene may be involved in the neoplastic process of some tumors.
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Cited by
Franco, B., Guioli, S., Pragliola, A., Incerti, B., Bardoni, B., Tonlorenzi, R., Carrozzo, R., Maestrini, E., Pieretti, M., Taillon-Miller, P., et al. (1991) · Nature · doi:10.1038/353529a0 · Cited by 846
Davis, S., Gale, N. W., Aldrich, T. H., Maisonpierre, P. C., Lhotak, V., Pawson, T., Goldfarb, M., & Yancopoulos, G. D. (1994) · Science · doi:10.1126/science.7973638 · Cited by 710
Miao, H., Li, D.-Q., Mukherjee, A., Guo, H., Petty, A., Cutter, J., Basilion, J. P., Sedor, J., Wu, J., Danielpour, D., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.04.009 · Cited by 533
Lai, C., & Lemke, G. (1991) · Neuron · doi:10.1016/0896-6273(91)90167-x · Cited by 443
The Drosophila gene torso encodes a putative receptor tyrosine kinase
Sprenger, F., Stevens, L. M., & Nüsslein-Volhard, C. (1989) · Nature · doi:10.1038/338478a0 · Cited by 317
Metadata
- Authors
- Hirai, H., Maru, Y., Hagiwara, K., Nishida, J., & Takaku, F.
- Venue
- Science
- Published
- 1987-12-18
- Volume
- 238
- Issue
- 4834
- Pages
- 1717-1720
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088023367
- Cited by
- 441
- References
- 0
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hirai, H., Maru, Y., Hagiwara, K., Nishida, J., & Takaku, F. (1987). A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene. Science. https://doi.org/10.1126/science.2825356
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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