The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity
Abstract
The EPH-related transmembrane tyrosine kinases constitute the largest known family of receptor-like tyrosine kinases, with many members displaying specific patterns of expression in the developing and adult nervous system. A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified. These ligands were unable to act as conventional soluble factors. However, they did function when presented in membrane-bound form, suggesting that they require direct cell-to-cell contact to activate their receptors. Membrane attachment may serve to facilitate ligand dimerization or aggregation, because antibody-mediated clustering activated previously inactive soluble forms of these ligands.
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Cites
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Cited by
Vascular-specific growth factors and blood vessel formation
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PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands
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Metadata
- Authors
- Davis, S., Gale, N. W., Aldrich, T. H., Maisonpierre, P. C., Lhotak, V., Pawson, T., Goldfarb, M., & Yancopoulos, G. D.
- Venue
- Science
- Published
- 1994-11-04
- Volume
- 266
- Issue
- 5186
- Pages
- 816-819
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034064964
- Cited by
- 710
- References
- 19
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Davis, S., Gale, N. W., Aldrich, T. H., Maisonpierre, P. C., Lhotak, V., Pawson, T., Goldfarb, M., & Yancopoulos, G. D. (1994). Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity. Science. https://doi.org/10.1126/science.7973638
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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