Cited by 263Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchAnimal Virus Infections Studies

Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research

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Koelle, David M., Corey, Lawrence·2003·Clinical Microbiology Reviews

Abstract

SUMMARY: Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) cause prevalent, chronic infections that have serious outcomes in some individuals. Neonatal herpes may occur when the infant traverses the cervix during maternal genital herpes. Genital herpes is a major risk factor for human immunodeficiency virus type 1 transmission. Considerable efforts have been made to design and test vaccines for HSV, focusing on genital infection with HSV-2. Several protein subunit vaccines based on HSV-2 envelope glycoproteins have reached advanced-phase clinical trials. These antigens were chosen because they are the targets of neutralizing-antibody responses and because they elicit cellular immunity. Encouraging results have been reported in studies of treatment of HSV-seronegative women with a vaccine consisting of truncated glycoprotein D of HSV-2 and a novel adjuvant. Because most sexual HSV transmission occurs during asymptomatic shedding, it is important to evaluate the impact of vaccination on HSV-2 infection, clinically apparent genital herpes, and HSV shedding among vaccine recipients who acquire infection. There are several other attractive formats, including subunit vaccines that target cellular immune responses, live attenuated virus strains, and mutant strains that undergo incomplete lytic replication. HSV vaccines have also been evaluated for the immunotherapy of established HSV infection.

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Crossref · 10.1128/cmr.16.1.96-113.2003

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Authors
Koelle, D. M., & Corey, L.
Affiliations
University of Washington (US)
Corresponding author
Koelle, David M.
Venue
Clinical Microbiology Reviews
Published
2003-01
Volume
16
Issue
1
Pages
96-113
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2158636026
Cited by
263
References
297
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 10 · 2016: 7 · 2015: 13 · 2014: 10 · 2013: 12 · 2012: 16
FWCI
3.16
Type
journal article
Language
en
Open access
Locations
  • Clinical Microbiology Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R21AI050132, AI 30731, P01AI030731, R01AI050132, AI 50132)
Topics
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords
herpes simplex virus, herpes simplex virus type 1, herpes simplex virus type 2, herpes vaccine, subunit vaccine, glycoproteins, glycoprotein D, adjuvants, genital herpes, neonatal herpes, HIV transmission, asymptomatic viral shedding, live attenuated vaccine, cell-mediated immunity, neutralizing antibodies
MeSH terms
Forecasting, Herpes Simplex, Humans, Viral Vaccines, Simplexvirus

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