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Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
Abstract
The function of the central cannabinoid receptor (CB 1 ) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB 1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome were strongly reduced. These observations suggest that the CB 1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB 1 and opiate receptors in the brain areas mediating addictive behavior.
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Cites
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Matthes, H. W. D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., Befort, K., Dierich, A., Le Meur, M., Dollé, P., et al. (1996) · Nature · doi:10.1038/383819a0 · Cited by 1,722
Self-citationActivation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal
Rodrı́guez de Fonseca, F., Carrera, M. R. A., Navarro, M., Koob, G. F., & Weiss, F. (1997) · Science · doi:10.1126/science.276.5321.2050 · Cited by 499
Research works printed but not linked: 20
- Felder C. C., Glass M., Annu. Rev. Pharmacol. Toxicol. 38, 179 (1998); · DOI · Paper page
- Abood M. E., Martin B. R., Int. Rev. Neurobiol. 39, 197 (1996). · DOI
- Gérard C., Mollereau C., Vassart G., Parmentier M., Biochem. J. 279, 129 (1991); · DOI · Paper page
- Ledent C., et al., Nature 388, 674 (1997); · DOI · Paper page
- Haycock D. A., J. Pharmacol. Exp. Ther. 264, 1352 (1993);
- 10.1038/28393 · DOI · Paper page
- Martellotta M. C., Cossu G., Fattore L., Gessa G. L., Fratta W., Neuroscience 85, 327 (1998)]. · DOI
- Hutcheson D. M., et al., Br. J. Pharmacol. 125, 1567 (1998)]. · DOI · Paper page
- Lake K. D., Compton D. R., Varga K., Martin B. R., Kunos G., J. Pharmacol. Exp. Therap. 281, 1030 (1997).
- Pedrazzini T., et al., Nature Med. 4, 722 (1998); · DOI · Paper page
- Welch S. P., Stevens D. L., J. Pharmacol. Exp. Ther. 262, 10 (1992).
- 10.1126/science.276.5321.2048 · DOI · Paper page
- Kuzmin A., Zvartau E., Gessa G. L., Martellotta M. C., Fratta W., Pharmacol. Biochem. Behav. 413, 497 (1992). · DOI
- 10.1126/science.273.5275.657 · DOI · Paper page
- Maldonado R., Negus S., Koob G. F., Neuropharmacology 21, 1231 (1992)]. · DOI
- Christie M. J., Williams J. T., North R. A., Mol. Pharmacol. 32, 633 (1987);
- ; E. L. Way in Opioids II A. Herz Ed. (Springer-Verlag Berlin 1993) pp. 573–592.
- Smith P. B., Welch S. P., Martin B. R., J. Pharmacol. Exp. Ther. 268, 1381 (1994).
- Lahti R. A., Von Voigtlander P. F., Barsuhn C., Life Sci. 31, 2257 (1982). · DOI · Paper page
- Simonin F., et al., EMBO J. 17, 886 (1998). · DOI · Paper page
Cited by
Neurobiology of addiction: a neurocircuitry analysis
Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957
Metadata
- Authors
- Ledent, C., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Imperato, A., Pedrazzini, T., Roques, B. P., Vassart, G., Fratta, W., & Parmentier, M.
- Venue
- Science
- Published
- 1999-01-15
- Volume
- 283
- Issue
- 5400
- Pages
- 401-404
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2171584675
- Cited by
- 3,614
- References
- 4
- FWCI
- 119.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice. https://app.cochat.ai/papers/10.1126/science.283.5400.401
- The paper
- Ledent, C., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Imperato, A., Pedrazzini, T., Roques, B. P., Vassart, G., Fratta, W., & Parmentier, M. (1999). Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice. Science. https://doi.org/10.1126/science.283.5400.401
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
