The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Diminishing Returns from Mutation Supply Rate in Asexual Populations
Open accessAbstract
Mutator genotypes with increased mutation rates may be especially important in microbial evolution if genetic adaptation is generally limited by the supply of mutations. In experimental populations of the bacterium Escherichia coli , the rate of evolutionary adaptation was proportional to the mutation supply rate only in particular circumstances of small or initially well-adapted populations. These experiments also demonstrate a “speed limit” on adaptive evolution in asexual populations, one that is independent of the mutation supply rate.
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Citations
Cites
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Fisher, R. A. (1930) · doi:10.5962/bhl.title.27468 · Cited by 17,617
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Self-citation(1991) · PubMed · Cited by 1,305
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Lenski, R. E., & Travisano, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.6808 · Cited by 1,016
Self-citationEvolution of high mutation rates in experimental populations of E. coli
Sniegowski, P. D., Gerrish, P. J., & Lenski, R. E. (1997) · Nature · doi:10.1038/42701 · Cited by 879
Self-citationHigh Mutation Frequencies Among Escherichia coli and Salmonella Pathogens
LeClerc, J. E., Li, B., Payne, W. L., & Cebula, T. A. (1996) · Science · doi:10.1126/science.274.5290.1208 · Cited by 817
The fate of competing beneficial mutations in an asexual population
Gerrish, P. J., & Lenski, R. E. (1998) · Genetica · doi:10.1023/a:1017067816551 · Cited by 772
Self-citationAdaptive evolution of highly mutable loci in pathogenic bacteria
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Cited by
Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation
Elena, S. F., & Lenski, R. E. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1088 · Cited by 1,386
Self-citationHorizontal gene transfer and adaptive evolution in bacteria.
Arnold, B. J., Huang, I.-T., & Hanage, W. P. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00650-4 · Cited by 869
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
Toprak, E., Veres, A., Michel, J.-B., Chait, R., Hartl, D. L., & Kishony, R. (2012) · Nature Genetics · doi:10.1038/ng.1034 · Cited by 764
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Self-citationListeria monocytogenes lineages: Genomics, evolution, ecology, and phenotypic characteristics
Orsi, R. H., Bakker, H. C. D., & Wiedmann, M. (2011) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.05.002 · Cited by 732
Metadata
- Authors
- Arjan G., J., Visser, M. D., Zeyl, C. W., Gerrish, P. J., Blanchard, J. L., & Lenski, R. E.
- Venue
- Science
- Published
- 1999-01-15
- Volume
- 283
- Issue
- 5400
- Pages
- 404-406
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1955582561
- Cited by
- 374
- References
- 21
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Arjan G., J., Visser, M. D., Zeyl, C. W., Gerrish, P. J., Blanchard, J. L., & Lenski, R. E. (1999). Diminishing Returns from Mutation Supply Rate in Asexual Populations. Science. https://doi.org/10.1126/science.283.5400.404
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
