Adaptive evolution of highly mutable loci in pathogenic bacteria

Moxon, E.Richard; Rainey, Paul B.; Nowak, Martin A.; Lenski, Richard E.

doi:10.1016/s0960-9822(00)00005-1

Cited by 755Evolution and Genetic DynamicsBacterial Genetics and BiotechnologyGenomics and Phylogenetic Studies

Adaptive evolution of highly mutable loci in pathogenic bacteria

Moxon, E.Richard, Rainey, Paul B., Nowak, Martin A., Lenski, Richard E.·1994·Current Biology

DOI 10.1016/s0960-9822(00)00005-1

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Abstract

Bacteria have specific loci that are highly mutable. We argue that the coexistence within bacterial genomes of such 'contingency' genes with high mutation rates, and 'housekeeping' genes with low mutation rates, is the result of adaptive evolution, and facilitates the efficient exploration of phenotypic solutions to unpredictable aspects of the host environment while minimizing deleterious effects on fitness.

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Previous explanations for possible mechanisms underlying chromosomal inversion included illegitimate recombination, intra-chromosomally homologous recombination, and integrase-mediated site-specific recombination.
“Based on these molecular evidences, previous explanations for the possible mechanisms underlying chromosomal inversion included illegitimate recombination,51–53 intra-chromosomally homologous recombination,54 as well as integrase-mediated site-specific recombination.55 , 56”
From Whole genomic DNA sequencing and comparative genomic analysis of<i>Arthrospira platensis</i>: high genome plasticity and genetic diversity (2016) · cites this paper as [52]

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Authors: Moxon, E. R., Rainey, P. B., Nowak, M. A., & Lenski, R. E.
Affiliations: John Radcliffe Hospital (GB)
University of Oxford (GB)
Michigan State University (US)
Corresponding author: Moxon, E.Richard
ORCID: Rainey, Paul B.
Nowak, Martin A.
Lenski, Richard E.
Venue: Current Biology
Publisher: Elsevier BV
Published: 1994-01
Volume: 4
Issue: 1
Pages: 24-33
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/s0960-9822(00)00005-1
OpenAlex: W2166160777
Cited by: 755
References: 68
Citations by year: 2026: 7 · 2025: 15 · 2024: 12 · 2023: 20 · 2022: 7 · 2021: 30 · 2020: 17 · 2019: 23 · 2018: 28 · 2017: 26 · 2016: 20 · 2015: 16 · 2014: 38 · 2013: 22 · 2012: 23
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: adaptive evolution, mutation rate, housekeeping genes, pathogenic bacteria, bacterial genomes, host environment
MeSH terms: Animals, Bacteria, Base Sequence, DNA, Bacterial, Biological Evolution, Gene Conversion, Genes, Bacterial, Haemophilus influenzae, Humans, Models, Genetic, Molecular Sequence Data, Mutation, Phenotype, Recombination, Genetic, Repetitive Sequences, Nucleic Acid

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Adaptive evolution of highly mutable loci in pathogenic bacteria

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